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51.

6100
Accesses

Research article   Open Access Highly Accessed

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling

Ethan A Winkler, Robert D Bell, Berislav V Zlokovic Molecular Neurodegeneration 2010, 5:32 (25 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

52.

5924
Accesses

Research article   Open Access Highly Accessed

6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death

Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malley Molecular Neurodegeneration 2011, 6:2 (6 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

53.

5919
Accesses

Methodology   Open Access

Independent component analysis of Alzheimer's DNA microarray gene expression data

Wei Kong, Xiaoyang Mou, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Xudong Huang Molecular Neurodegeneration 2009, 4:5 (28 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

54.

5894
Accesses

Review   Open Access Highly Accessed

Alzheimer's disease: synapses gone cold

Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones Molecular Neurodegeneration 2011, 6:63 (26 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

55.

5805
Accesses

Research article   Open Access Highly Accessed

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

Fanjun Meng, Dongdong Yao, Yang Shi, Jonathan Kabakoff, Wei Wu, Joshua Reicher, Yuliang Ma, Bernd Moosmann, Eliezer Masliah, Stuart A Lipton, Zezong Gu Molecular Neurodegeneration 2011, 6:34 (19 May 2011)

Abstract | Full text | PDF | PubMed

56.

5772
Accesses

Research article   Open Access

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

Thuzar M Shin, J Mario Isas, Chia-Ling Hsieh, Rakez Kayed, Charles G Glabe, Ralf Langen, Jeannie Chen Molecular Neurodegeneration 2008, 3:16 (21 October 2008)

Abstract | Full text | PDF | PubMed

57.

5761
Accesses

Research article   Open Access

Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons

Jian-Sheng Gong, Shin-ya Morita, Mariko Kobayashi, Tetsurou Handa, Shinobu C Fujita, Katsuhiko Yanagisawa, Makoto Michikawa Molecular Neurodegeneration 2007, 2:9 (15 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

58.

5747
Accesses

Research article   Open Access Highly Accessed

Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains

Stéphanie Baulac, Hope Lu, Jennifer Strahle, Ting Yang, Matthew S Goldberg, Jie Shen, Michael G Schlossmacher, Cynthia A Lemere, Qun Lu, Weiming Xia Molecular Neurodegeneration 2009, 4:12 (25 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

59.

5734
Accesses

Research article   Open Access Highly Accessed

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Rodrigo A Fuentealba, Maria Barría, Jiyeon Lee, Judy Cam, Claudia Araya, Claudia A Escudero, Nibaldo C Inestrosa, Francisca C Bronfman, Guojun Bu, Maria-Paz Marzolo Molecular Neurodegeneration 2007, 2:14 (9 July 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

60.

5588
Accesses

Research article   Open Access Highly Accessed

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

John W Steele, Soong H Kim, John R Cirrito, Deborah K Verges, Jessica L Restivo, David Westaway, Paul Fraser, Peter Hyslop, Mary Sano, Ilya Bezprozvanny, Michelle E Ehrlich, David M Holtzman, Sam Gandy Molecular Neurodegeneration 2009, 4:51 (17 December 2009)

Abstract | Full text | PDF | PubMed | F1000 |  Editor’s summary

Latrepirdine, which improves cognitive function in patients with mild to moderate Alzheimer’s disease, elevates extracellular amyloid-beta peptide levels in three model systems, running counter to the action of the most popular anti-amyloid agents currently under development.

61.

5573
Accesses

Research article   Open Access

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates

Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah, Todd E Golde Molecular Neurodegeneration 2006, 1:3 (12 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

62.

5492
Accesses

Research article   Open Access Highly Accessed

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel Molecular Neurodegeneration 2011, 6:36 (27 May 2011)

Abstract | Full text | PDF | PubMed | 1 comment

63.

5489
Accesses

Research article   Open Access Highly Accessed

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

Iliya Lefterov, Angie Bookout, Zhu Wang, Matthias Staufenbiel, David Mangelsdorf, Radosveta Koldamova Molecular Neurodegeneration 2007, 2:20 (22 October 2007)

Abstract | Full text | PDF | PubMed

64.

5486
Accesses

Research article   Open Access Highly Accessed

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms

Suzanne E Wahrle, Aarti R Shah, Anne M Fagan, Scott Smemo, John SK Kauwe, Andrew Grupe, Anthony Hinrichs, Kevin Mayo, Hong Jiang, Leon J Thal, Alison M Goate, David M Holtzman Molecular Neurodegeneration 2007, 2:7 (12 April 2007)

Abstract | Full text | PDF | PubMed

65.

5440
Accesses

Research article   Open Access Highly Accessed

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.

66.

5411
Accesses

Research article   Open Access

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton, Christopher B Eckman Molecular Neurodegeneration 2006, 1:6 (26 July 2006)

Abstract | Full text | PDF | PubMed

67.

5373
Accesses

Short report   Open Access

MicroRNAs can regulate human APP levels

Neha Patel, David Hoang, Nathan Miller, Sara Ansaloni, Qihong Huang, Jack T Rogers, Jeremy C Lee, Aleister J Saunders Molecular Neurodegeneration 2008, 3:10 (6 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

68.

5246
Accesses

Research article   Open Access Highly Accessed

Dopamine and α-synuclein dysfunction in Smad3 null mice

Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capelo Molecular Neurodegeneration 2011, 6:72 (13 October 2011)

Abstract | Full text | PDF | PubMed | 1 comment

69.

5218
Accesses

Research article   Open Access Highly Accessed

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

Young-Don Kwak, Tao Ma, Shiyong Diao, Xue Zhang, Yaomin Chen, Janet Hsu, Stuart A Lipton, Eliezer Masliah, Huaxi Xu, Francesca-Fang Liao Molecular Neurodegeneration 2010, 5:49 (10 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

70.

5212
Accesses

Research article   Open Access

Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease

Wei-Guo Liu, Xi-Jing Wang, Guo-Qiang Lu, Biao Li, Gang Wang, Sheng-Di Chen Molecular Neurodegeneration 2007, 2:19 (1 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

71.

5205
Accesses

Research article   Open Access

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells

Andrew C Nyborg, Lauren Herl, Oksana Berezovska, Anne V Thomas, Thomas B Ladd, Karen Jansen, Bradley T Hyman, Todd E Golde Molecular Neurodegeneration 2006, 1:16 (14 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

72.

5203
Accesses

Research article   Open Access

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Jaya RP Prasanthi, Amber Huls, Sarah Thomasson, Alex Thompson, Eric Schommer, Othman Ghribi Molecular Neurodegeneration 2009, 4:1 (6 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

73.

5174
Accesses

Research article   Open Access Highly Accessed

Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice

Hiroo Yamaguchi, Jie Shen Molecular Neurodegeneration 2007, 2:10 (29 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

74.

5143
Accesses

Research article   Open Access Highly Accessed

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

Preeti J Khandelwal, Sonya B Dumanis, Li Feng, Kathleen Maguire-Zeiss, GW Rebeck, Hilal A Lashuel, Charbel EH Moussa Molecular Neurodegeneration 2010, 5:47 (4 November 2010)

Abstract | Full text | PDF | PubMed

75.

5091
Accesses

Research article   Open Access

A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation

Qing Liu, Joy X Lei, Marianna Sikorska, Rugao Liu Molecular Neurodegeneration 2008, 3:4 (25 February 2008)

Abstract | Full text | PDF | PubMed

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