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51.
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Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
Ethan A Winkler, Robert D Bell, Berislav V Zlokovic Molecular Neurodegeneration 2010, 5:32 (25 August 2010)
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52.
5924 Accesses
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6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malley Molecular Neurodegeneration 2011, 6:2 (6 January 2011)
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53.
5919 Accesses
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Independent component analysis of Alzheimer's DNA microarray gene expression data
Wei Kong, Xiaoyang Mou, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Xudong Huang Molecular Neurodegeneration 2009, 4:5 (28 January 2009)
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54.
5894 Accesses
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Alzheimer's disease: synapses gone cold
Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones Molecular Neurodegeneration 2011, 6:63 (26 August 2011)
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55.
5805 Accesses
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Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
Fanjun Meng, Dongdong Yao, Yang Shi, Jonathan Kabakoff, Wei Wu, Joshua Reicher, Yuliang Ma, Bernd Moosmann, Eliezer Masliah, Stuart A Lipton, Zezong Gu Molecular Neurodegeneration 2011, 6:34 (19 May 2011)
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56.
5772 Accesses
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Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
Thuzar M Shin, J Mario Isas, Chia-Ling Hsieh, Rakez Kayed, Charles G Glabe, Ralf Langen, Jeannie Chen Molecular Neurodegeneration 2008, 3:16 (21 October 2008)
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57.
5761 Accesses
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Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons
Jian-Sheng Gong, Shin-ya Morita, Mariko Kobayashi, Tetsurou Handa, Shinobu C Fujita, Katsuhiko Yanagisawa, Makoto Michikawa Molecular Neurodegeneration 2007, 2:9 (15 May 2007)
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58.
5747 Accesses
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Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
Stéphanie Baulac, Hope Lu, Jennifer Strahle, Ting Yang, Matthew S Goldberg, Jie Shen, Michael G Schlossmacher, Cynthia A Lemere, Qun Lu, Weiming Xia Molecular Neurodegeneration 2009, 4:12 (25 February 2009)
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59.
5734 Accesses
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ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity
Rodrigo A Fuentealba, Maria Barría, Jiyeon Lee, Judy Cam, Claudia Araya, Claudia A Escudero, Nibaldo C Inestrosa, Francisca C Bronfman, Guojun Bu, Maria-Paz Marzolo Molecular Neurodegeneration 2007, 2:14 (9 July 2007)
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60.
5588 Accesses
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Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo
John W Steele, Soong H Kim, John R Cirrito, Deborah K Verges, Jessica L Restivo, David Westaway, Paul Fraser, Peter Hyslop, Mary Sano, Ilya Bezprozvanny, Michelle E Ehrlich, David M Holtzman, Sam Gandy Molecular Neurodegeneration 2009, 4:51 (17 December 2009)
Abstract | Full text | PDF
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| F1000
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Editor’s summary
Latrepirdine, which improves cognitive function in patients with mild to moderate Alzheimer’s disease, elevates extracellular amyloid-beta peptide levels in three model systems, running counter to the action of the most popular anti-amyloid agents currently under development.
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61.
5573 Accesses
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Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah, Todd E Golde Molecular Neurodegeneration 2006, 1:3 (12 June 2006)
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62.
5492 Accesses
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Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel Molecular Neurodegeneration 2011, 6:36 (27 May 2011)
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63.
5489 Accesses
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Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment
Iliya Lefterov, Angie Bookout, Zhu Wang, Matthias Staufenbiel, David Mangelsdorf, Radosveta Koldamova Molecular Neurodegeneration 2007, 2:20 (22 October 2007)
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64.
5486 Accesses
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Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms
Suzanne E Wahrle, Aarti R Shah, Anne M Fagan, Scott Smemo, John SK Kauwe, Andrew Grupe, Anthony Hinrichs, Kevin Mayo, Hong Jiang, Leon J Thal, Alison M Goate, David M Holtzman Molecular Neurodegeneration 2007, 2:7 (12 April 2007)
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65.
5440 Accesses
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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)
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Editor’s summary
BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.
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66.
5411 Accesses
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Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression
Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton, Christopher B Eckman Molecular Neurodegeneration 2006, 1:6 (26 July 2006)
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67.
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MicroRNAs can regulate human APP levels
Neha Patel, David Hoang, Nathan Miller, Sara Ansaloni, Qihong Huang, Jack T Rogers, Jeremy C Lee, Aleister J Saunders Molecular Neurodegeneration 2008, 3:10 (6 August 2008)
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68.
5246 Accesses
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Dopamine and α-synuclein dysfunction in Smad3 null mice
Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capelo Molecular Neurodegeneration 2011, 6:72 (13 October 2011)
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69.
5218 Accesses
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NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
Young-Don Kwak, Tao Ma, Shiyong Diao, Xue Zhang, Yaomin Chen, Janet Hsu, Stuart A Lipton, Eliezer Masliah, Huaxi Xu, Francesca-Fang Liao Molecular Neurodegeneration 2010, 5:49 (10 November 2010)
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70.
5212 Accesses
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Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease
Wei-Guo Liu, Xi-Jing Wang, Guo-Qiang Lu, Biao Li, Gang Wang, Sheng-Di Chen Molecular Neurodegeneration 2007, 2:19 (1 October 2007)
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71.
5205 Accesses
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Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells
Andrew C Nyborg, Lauren Herl, Oksana Berezovska, Anne V Thomas, Thomas B Ladd, Karen Jansen, Bradley T Hyman, Todd E Golde Molecular Neurodegeneration 2006, 1:16 (14 November 2006)
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72.
5203 Accesses
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Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
Jaya RP Prasanthi, Amber Huls, Sarah Thomasson, Alex Thompson, Eric Schommer, Othman Ghribi Molecular Neurodegeneration 2009, 4:1 (6 January 2009)
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73.
5174 Accesses
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Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice
Hiroo Yamaguchi, Jie Shen Molecular Neurodegeneration 2007, 2:10 (29 May 2007)
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74.
5143 Accesses
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Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model
Preeti J Khandelwal, Sonya B Dumanis, Li Feng, Kathleen Maguire-Zeiss, GW Rebeck, Hilal A Lashuel, Charbel EH Moussa Molecular Neurodegeneration 2010, 5:47 (4 November 2010)
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75.
5091 Accesses
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A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation
Qing Liu, Joy X Lei, Marianna Sikorska, Rugao Liu Molecular Neurodegeneration 2008, 3:4 (25 February 2008)
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