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26.

7935
Accesses

Review   Open Access Highly Accessed

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Nibaldo C Inestrosa, Enrique M Toledo Molecular Neurodegeneration 2008, 3:9 (24 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

7725
Accesses

Short report   Open Access Highly Accessed

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

Danling Wang, Beisha Tang, Guohua Zhao, Qian Pan, Kun Xia, Rolf Bodmer, Zhuohua Zhang Molecular Neurodegeneration 2008, 3:3 (8 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

7684
Accesses

Research article   Open Access Highly Accessed

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Kiran Bhaskar, Megan Miller, Alexandra Chludzinski, Karl Herrup, Michael Zagorski, Bruce T Lamb Molecular Neurodegeneration 2009, 4:14 (16 March 2009)

Abstract | Full text | PDF | PubMed

29.

7579
Accesses

Research article   Open Access Highly Accessed

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

Kulandaivelu S Vetrivel, Ping Gong, James W Bowen, Haipeng Cheng, Ying Chen, Meghan Carter, Phuong D Nguyen, Lisa Placanica, Felix T Wieland, Yue-Ming Li, Maria Z Kounnas, Gopal Thinakaran Molecular Neurodegeneration 2007, 2:4 (8 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

7528
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Research article   Open Access Highly Accessed

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

Xiaofeng Gu, Véronique M André, Carlos Cepeda, Shi-Hua Li, Xiao-Jiang Li, Michael S Levine, X William Yang Molecular Neurodegeneration 2007, 2:8 (30 April 2007)

Abstract | Full text | PDF | PubMed

31.

7468
Accesses

Research article   Open Access Highly Accessed

Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau

Ismael Santa-Maria, Félix Hernández, Joaquín Del Rio, Francisco J Moreno, Jesús Avila Molecular Neurodegeneration 2007, 2:17 (6 September 2007)

Abstract | Full text | PDF | PubMed

32.

7178
Accesses

Research article   Open Access

Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra

Tom N Grammatopoulos, Susan M Jones, Ferogh A Ahmadi, Brian R Hoover, Lawrence D Snell, Jesse Skoch, Vimal V Jhaveri, Andy M Poczobutt, James A Weyhenmeyer, W Michael Zawada Molecular Neurodegeneration 2007, 2:1 (15 January 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

7151
Accesses

Review   Open Access Highly Accessed

Multiple pathways contribute to the pathogenesis of Huntington disease

Shihua Li, Xiao-Jiang Li Molecular Neurodegeneration 2006, 1:19 (16 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

7106
Accesses

Review   Open Access Highly Accessed

Biology and pathophysiology of the amyloid precursor protein

Hui Zheng, Edward H Koo Molecular Neurodegeneration 2011, 6:27 (28 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

7100
Accesses

Research article   Open Access

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

M Kathleen Borland, Patricia A Trimmer, Jeremy D Rubinstein, Paula M Keeney, KP Mohanakumar, Lei Liu, James P Bennett Molecular Neurodegeneration 2008, 3:21 (29 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

7060
Accesses

Research article   Open Access Highly Accessed

GSK3 and p53 - is there a link in Alzheimer's disease?

Carole J Proctor, Douglas A Gray Molecular Neurodegeneration 2010, 5:7 (26 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

6794
Accesses

Research article   Open Access Highly Accessed

Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy

Patricia A Trimmer, Kathleen M Schwartz, M Kathleen Borland, Luis De Taboada, Jackson Streeter, Uri Oron Molecular Neurodegeneration 2009, 4:26 (17 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

6708
Accesses

Research article   Open Access Highly Accessed

Evaluation of Dimebon in cellular model of Huntington's disease

Jun Wu, Qin Li, Ilya Bezprozvanny Molecular Neurodegeneration 2008, 3:15 (21 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

6470
Accesses

Research article   Open Access Highly Accessed

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

Richard C Davis, Ian T Marsden, Michael T Maloney, Laurie S Minamide, Marcia Podlisny, Dennis J Selkoe, James R Bamburg Molecular Neurodegeneration 2011, 6:10 (24 January 2011)

Abstract | Full text | PDF | PubMed

40.

6424
Accesses

Review   Open Access

Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease

Lonnie Schneider, Jianhua Zhang Molecular Neurodegeneration 2010, 5:14 (13 April 2010)

Abstract | Full text | PDF | PubMed

41.

6404
Accesses

Research article   Open Access

Autoimmune-induced preferential depletion of myelin-associated glycoprotein (MAG) is genetically regulated in relapsing EAE (B6 × SJL) F1 mice

Dusanka S Skundric, Rujuan Dai, Vaagn L Zakarian, Weili Zhou Molecular Neurodegeneration 2008, 3:7 (9 June 2008)

Abstract | Full text | PDF | PubMed

42.

6361
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Research article   Open Access Highly Accessed

Neuroprotective effects of blockers for T-type calcium channels

Norelle C Wildburger, Avary Lin-Ye, Michelle A Baird, Debin Lei, Jianxin Bao Molecular Neurodegeneration 2009, 4:44 (28 October 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cognitive and functional decline resulting from neuronal death mediated by intracellular calcium deregulation is halted by T-type calcium channel antagonists, suggesting that they could be used to treat neurodegenerative conditions.

43.

6344
Accesses

Review   Open Access

Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease

Marwa Aboukhatwa, Laura Dosanjh, Yuan Luo Molecular Neurodegeneration 2010, 5:10 (12 March 2010)

Abstract | Full text | PDF | PubMed

44.

6299
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Review   Open Access Highly Accessed

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

Dale E Bredesen Molecular Neurodegeneration 2009, 4:27 (26 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

6266
Accesses

Research article   Open Access Highly Accessed

Localization of BDNF mRNA with the Huntington's disease protein in rat brain

Bin Ma, Brady P Culver, Gabriele Baj, Enrico Tongiorgi, Moses V Chao, Naoko Tanese Molecular Neurodegeneration 2010, 5:22 (27 May 2010)

Abstract | Full text | PDF | PubMed

46.

6221
Accesses

Research article   Open Access Highly Accessed

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Subbiah Pugazhenthi, Maorong Wang, Serena Pham, Chun-I Sze, Christopher B Eckman Molecular Neurodegeneration 2011, 6:60 (19 August 2011)

Abstract | Full text | PDF | PubMed

47.

6190
Accesses

Research article   Open Access

Tetrabenazine is neuroprotective in Huntington's disease mice

Hongyu Wang, Xi Chen, Yuemei Li, Tie-Shan Tang, Ilya Bezprozvanny Molecular Neurodegeneration 2010, 5:18 (26 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

6162
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Research article   Open Access Highly Accessed

Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

Verena Kallhoff, Erica Peethumnongsin, Hui Zheng Molecular Neurodegeneration 2007, 2:6 (16 March 2007)

Abstract | Full text | PDF | PubMed

49.

6119
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Research article   Open Access Highly Accessed

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

Xiao-dong Pan, Yuan-gui Zhu, Nan Lin, Jing Zhang, Qin-yong Ye, Hua-pin Huang, Xiao-chun Chen Molecular Neurodegeneration 2011, 6:45 (30 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

6102
Accesses

Commentary   Open Access

"What kills neurons in neurodegenerative diseases?", a review series in an open access journal

Todd E Golde, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:7 (4 February 2009)

Abstract | Full text | PDF | PubMed

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