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ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelson Molecular Neurodegeneration 2013, 8:16 (17 May 2013)
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Normal cognition in transgenic BRI2-Aβ mice
Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013)
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Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado Molecular Neurodegeneration 2013, 8:14 (26 April 2013)
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In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013)
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Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw Molecular Neurodegeneration 2013, 8:12 (8 April 2013)
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Reviewer acknowledgement
Guojun Bu, Huaxi Xu Molecular Neurodegeneration 2013, 8:11 (2 April 2013)
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Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013)
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In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau
p301l) reveals reduced neural activity in memory formation structures
Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara Molecular Neurodegeneration 2013, 8:9 (4 February 2013)
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Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Ceru', Sandra Moreno Molecular Neurodegeneration 2013, 8:8 (2 February 2013)
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HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet Molecular Neurodegeneration 2013, 8:7 (29 January 2013)
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Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression
Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett, Patricia A Trimmer Molecular Neurodegeneration 2013, 8:6 (26 January 2013)
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Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013)
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Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma
Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe Molecular Neurodegeneration 2013, 8:4 (18 January 2013)
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Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
Guo-Jun Chen, Zhe Xiong, Zhen Yan Molecular Neurodegeneration 2013, 8:3 (17 January 2013)
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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
William A Eimer, Robert Vassar Molecular Neurodegeneration 2013, 8:2 (14 January 2013)
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Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, Zuoshang Xu Molecular Neurodegeneration 2013, 8:1 (3 January 2013)
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Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka, Zhiming Tu, Faris Albayya, Winnie Lee, Sarah Hopp, Mary-Jo Miller, Darcie Spaulding, Zhiyong Yang, Hilliary Hodgdon, Scott Nolan, Melody Wen, Don Costa, Jean-Francois Blain, Emily Freeman, Bart De Strooper, Veerle Vulsteke, Louise Scrocchi, Henrik Zetterberg, Erik Portelius, Birgit Hutter-Paier, Daniel Havas, Michael Ahlijanian, Dorothy Flood, Liza Leventhal, Gideon Shapiro, Holger Patzke, Richard Chesworth, Gerhard Koenig et al.
Molecular Neurodegeneration 2012, 7:61 (18 December 2012)
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Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
Robert Tamayev, Nsikan Akpan, Ottavio Arancio, Carol M Troy, Luciano D’Adamio Molecular Neurodegeneration 2012, 7:60 (10 December 2012)
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo, Victoria Navarro, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Irene Carmona, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica Molecular Neurodegeneration 2012, 7:59 (22 November 2012)
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The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
Hannah Brautigam, John W Steele, David Westaway, Paul E Fraser, Peter H St George-Hyslop, Sam Gandy, Patrick R Hof, Dara L Dickstein Molecular Neurodegeneration 2012, 7:58 (22 November 2012)
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Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease
Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny Molecular Neurodegeneration 2012, 7:57 (21 November 2012)
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Regulated protein aggregation: stress granules and neurodegeneration
Benjamin Wolozin Molecular Neurodegeneration 2012, 7:56 (20 November 2012)
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Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
Alexander Slowik, Julika Merres, Anne Elfgen, Sandra Jansen, Fabian Mohr, Christoph J Wruck, Thomas Pufe, Lars-Ove Brandenburg Molecular Neurodegeneration 2012, 7:55 (20 November 2012)
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Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde Molecular Neurodegeneration 2012, 7:54 (24 October 2012)
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Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
Christophe Verbeeck, Qiudong Deng, Mariely DeJesus-Hernandez, Georgia Taylor, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W Dickson, Thomas Kukar Molecular Neurodegeneration 2012, 7:53 (10 October 2012)
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BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease
Linda Chami, Frédéric Checler Molecular Neurodegeneration 2012, 7:52 (5 October 2012)
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Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
Carolina Franco, Silvia Fernández, Ignacio Torres-Alemán Molecular Neurodegeneration 2012, 7:51 (5 October 2012)
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Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
Yuhki Saito, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Nobuyuki Kimura, Shigeo Murayama, Sunao Kaneko, Ryuichi Shigemoto, Keiji Imoto, Toshiharu Suzuki Molecular Neurodegeneration 2012, 7:50 (3 October 2012)
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Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease
Paula Desplats, Pruthul Patel, Kori Kosberg, Michael Mante, Christina Patrick, Edward Rockenstein, Masayo Fujita, Makoto Hashimoto, Eliezer Masliah Molecular Neurodegeneration 2012, 7:49 (28 September 2012)
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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
Keiichi Inoue, Joanne Rispoli, Hanoch Kaphzan, Eric Klann, Emily I Chen, Jongpil Kim, Masaaki Komatsu, Asa Abeliovich Molecular Neurodegeneration 2012, 7:48 (21 September 2012)
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IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery
Hong Lian, David J Shim, Samson SK Gaddam, Jennifer Rodriguez-Rivera, Brittany R Bitner, Robia G Pautler, Claudia S Robertson, Hui Zheng Molecular Neurodegeneration 2012, 7:47 (19 September 2012)
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Identification of BACE2 as an avid ß-amyloid-degrading protease
Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring Molecular Neurodegeneration 2012, 7:46 (17 September 2012)
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Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Terina N Martinez, Xi Chen, Sibali Bandyopadhyay, Alfred H Merrill, Malú G Tansey Molecular Neurodegeneration 2012, 7:45 (13 September 2012)
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Neuromuscular effects of G93A-SOD1 expression in zebrafish
Stacey A Sakowski, J Lunn, Angela S Busta, Sang Oh, Grettel Zamora-Berridi, Madeline Palmer, Andrew A Rosenberg, Stephen G Philip, James J Dowling, Eva L Feldman Molecular Neurodegeneration 2012, 7:44 (31 August 2012)
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ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba, Nobuyuki Nukina Molecular Neurodegeneration 2012, 7:43 (28 August 2012)
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Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg, Pamela J McLean Molecular Neurodegeneration 2012, 7:42 (24 August 2012)
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Mass spectrometry quantification of clusterin in the human brain
Junjun Chen, Meiyao Wang, Illarion V Turko Molecular Neurodegeneration 2012, 7:41 (20 August 2012)
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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
Haigang Ren, Kai Fu, Chenchen Mu, Xuechu Zhen, Guanghui Wang Molecular Neurodegeneration 2012, 7:40 (14 August 2012)
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Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
Pritam Das, Christophe Verbeeck, Lisa Minter, Paramita Chakrabarty, Kevin Felsenstein, Thomas Kukar, Ghulam Maharvi, Abdul Fauq, Barbara A Osborne, Todd E Golde Molecular Neurodegeneration 2012, 7:39 (14 August 2012)
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Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
Masatoshi Konno, Takafumi Hasegawa, Toru Baba, Emiko Miura, Naoto Sugeno, Akio Kikuchi, Fabienne C Fiesel, Tsutomu Sasaki, Masashi Aoki, Yasuto Itoyama, Atsushi Takeda Molecular Neurodegeneration 2012, 7:38 (14 August 2012)
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| PubMed | Cited on BioMed Central
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Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Suhail Rasool, Ricardo Albay, Hilda Martinez-Coria, Leonid Breydo, Jessica Wu, Saskia Milton, Sunit Misra, Andy Tran, Anna Pensalfini, Frank Laferla, Rakez Kayed, Charles G Glabe Molecular Neurodegeneration 2012, 7:37 (6 August 2012)
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Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
Paramita Chakrabarty, Li Tianbai, Amanda Herring, Carolina Ceballos-Diaz, Pritam Das, Todd E Golde Molecular Neurodegeneration 2012, 7:36 (29 July 2012)
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Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level
Georg Nübling, Benedikt Bader, Johannes Levin, Jenna Hildebrandt, Hans Kretzschmar, Armin Giese Molecular Neurodegeneration 2012, 7:35 (23 July 2012)
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Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system
Victor Ribeiro-Resende, Alvaro Carrier-Ruiz, Robertha M R Lemes, Ricardo A M Reis, Rosalia Mendez-Otero Molecular Neurodegeneration 2012, 7:34 (13 July 2012)
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Progranulin regulates neuronal outgrowth independent of Sortilin
Jennifer Gass, Wing C Lee, Casey Cook, Nicole Finch, Caroline Stetler, Karen Jansen-West, Jada Lewis, Christopher D Link, Rosa Rademakers, Anders Nykjær, Leonard Petrucelli Molecular Neurodegeneration 2012, 7:33 (10 July 2012)
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Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach
Carole J Proctor, Ilse Pienaar, Joanna L Elson, Thomas BL Kirkwood Molecular Neurodegeneration 2012, 7:32 (2 July 2012)
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LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
Julie Brodeur, Caroline Thériault, Mélissa Lessard-Beaudoin, Alexandre Marcil, Sophie Dahan, Christine Lavoie Molecular Neurodegeneration 2012, 7:31 (26 June 2012)
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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Yonghao Zhao, Yunshu Wang, Jiaye Yang, Xin Wang, Yingjun Zhao, Xian Zhang, Yun-wu Zhang Molecular Neurodegeneration 2012, 7:30 (18 June 2012)
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Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
Cheng Fang, Dennis Bourdette, Gary Banker Molecular Neurodegeneration 2012, 7:29 (18 June 2012)
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Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
Shaefali P Rodgers, Heather A Born, Pritam Das, Joanna L Jankowsky Molecular Neurodegeneration 2012, 7:28 (18 June 2012)
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Does a loss of TDP-43 function cause neurodegeneration?
Zuo-Shang Xu Molecular Neurodegeneration 2012, 7:27 (14 June 2012)
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A molecular signature in blood identifies early Parkinson’s disease
Leonid Molochnikov, Jose M Rabey, Evgenya Dobronevsky, Ubaldo Bonuccelli, Roberto Ceravolo, Daniela Frosini, Edna Grünblatt, Peter Riederer, Christian Jacob, Judith Aharon-Peretz, Yulia Bashenko, Moussa BH Youdim, Silvia A Mandel Molecular Neurodegeneration 2012, 7:26 (31 May 2012)
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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany Dugger, Beate Winner, Iryna Prots, Caroline B Kent, Kenya Nishioka, Wen-Lang Lin, Dennis W Dickson, Christopher J Janus, Matthew J Farrer, Heather L Melrose Molecular Neurodegeneration 2012, 7:25 (30 May 2012)
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Editor’s summary
LRRK2 knockout mice have a normal dopaminergic system and do not develop any pathological features of Parkinsons disease, but they do display altered exploratory and motor co-ordination behaviors, and degeneration in the kidney.
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Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
Zhao-Hui Xu, Qi Yang, Bin Feng, Shui-bing Liu, Nan Zhang, Jiang-hao Xing, Xiao-Qiang Li, Yu-mei Wu, Guo-Dong Gao, Ming-Gao Zhao Molecular Neurodegeneration 2012, 7:24 (28 May 2012)
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Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
Nicole L Bjorklund, Lindsay C Reese, V-M Sadagoparamanujam, Valeria Ghirardi, Randall L Woltjer, Giulio Taglialatela Molecular Neurodegeneration 2012, 7:23 (28 May 2012)
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Regulation of mitochondrial permeability transition pore by PINK1
Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Núñez, Zhiyin Song, David Chan, Carlos Villalobos, Jie Shen Molecular Neurodegeneration 2012, 7:22 (25 May 2012)
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Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia
Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun, Zezong Gu Molecular Neurodegeneration 2012, 7:21 (15 May 2012)
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Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease
Keizo Sugaya, Shiro Matsubara Molecular Neurodegeneration 2012, 7:20 (14 May 2012)
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Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
Robert Tamayev, Luciano D’Adamio Molecular Neurodegeneration 2012, 7:19 (26 April 2012)
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Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity
Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins Molecular Neurodegeneration 2012, 7:18 (26 April 2012)
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Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia
Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren, Changlian Zhu Molecular Neurodegeneration 2012, 7:17 (25 April 2012)
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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects
Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki, the Japanese Alzheimer's Disease Neuroimaging Initiative Molecular Neurodegeneration 2012, 7:16 (25 April 2012)
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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima, Sadahiro Azuma, Etsuro Ohta, Fumiya Obata Molecular Neurodegeneration 2012, 7:15 (25 April 2012)
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Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling
Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman, David M Holtzman Molecular Neurodegeneration 2012, 7:14 (18 April 2012)
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Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
Mariet Allen, Fanggeng Zou, High Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak, Sumit Middha, Sooraj Maharjan, Constantin Georgescu, Debra Schultz, Fariborz Rakhshan, Christopher P Kolbert, Jin Jen, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner et al.
Molecular Neurodegeneration 2012, 7:13 (11 April 2012)
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Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine, Marie-Françoise Chesselet Molecular Neurodegeneration 2012, 7:12 (4 April 2012)
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Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo, Francisca C Bronfman Molecular Neurodegeneration 2012, 7:11 (29 March 2012)
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Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia Molecular Neurodegeneration 2012, 7:10 (24 March 2012)
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FE65 as a link between VLDLR and APP to regulate their trafficking and processing
Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guénette, Toshiharu Suzuki, Paul M Mathews, Daniel TS Pak, G William Rebeck, Yoo-hun Suh, Hee-Sae Park, Hyang-Sook Hoe Molecular Neurodegeneration 2012, 7:9 (19 March 2012)
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Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley, Mary Jo LaDu Molecular Neurodegeneration 2012, 7:8 (16 March 2012)
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Rapid glutamate receptor 2 trafficking during retinal degeneration
Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc Molecular Neurodegeneration 2012, 7:7 (10 February 2012)
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Spinal cord trauma and the molecular point of no return
Ping K Yip, Andrea Malaspina Molecular Neurodegeneration 2012, 7:6 (8 February 2012)
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WldS
but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
Jo Ann V Antenor-Dorsey, Karen L O'Malley Molecular Neurodegeneration 2012, 7:5 (8 February 2012)
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Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
Xin Heng, Gang Jin, Xin Zhang, Dehuang Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le Molecular Neurodegeneration 2012, 7:4 (2 February 2012)
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Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven Molecular Neurodegeneration 2012, 7:3 (16 January 2012)
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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen Molecular Neurodegeneration 2012, 7:2 (9 January 2012)
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Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde, Domenico Pratico Molecular Neurodegeneration 2012, 7:1 (5 January 2012)
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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)
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Editor’s summary
BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.
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Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent, Gopal Thinakaran Molecular Neurodegeneration 2011, 6:87 (28 December 2011)
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Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Byung Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel Molecular Neurodegeneration 2011, 6:86 (22 December 2011)
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Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)
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Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
Bin Xing, Adam D Bachstetter, Linda J Van Eldik Molecular Neurodegeneration 2011, 6:84 (20 December 2011)
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Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet, Robert H Schiestl Molecular Neurodegeneration 2011, 6:83 (13 December 2011)
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Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
Yair M Gozal, Nicholas T Seyfried, Marla Gearing, Jonathan D Glass, Craig J Heilman, Joanne Wuu, Duc M Duong, Dongmei Cheng, Qiangwei Xia, Howard D Rees, Jason J Fritz, Deborah S Cooper, Junmin Peng, Allan I Levey, James J Lah Molecular Neurodegeneration 2011, 6:82 (29 November 2011)
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Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet, Ilya Bezprozvanny Molecular Neurodegeneration 2011, 6:81 (25 November 2011)
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Editor’s summary
Dantrolene, a RyanR inhibitor and calcium signalling stabilizer, is identified as a potential agent for the treatment of Huntingdons Disease, further implicating the disturbance of intracellular calcium signalling in the pathogenesis of polyglutamine expansion diseases.
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Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes
Monique Judge, Lisa Hornbeck, Huntington Potter, Jaya Padmanabhan Molecular Neurodegeneration 2011, 6:80 (23 November 2011)
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Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
Xinyi Li, Joel N Buxbaum Molecular Neurodegeneration 2011, 6:79 (23 November 2011)
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Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp, Kurt F Hauser Molecular Neurodegeneration 2011, 6:78 (17 November 2011)
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Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
Mercedes Prudencio, David R Borchelt Molecular Neurodegeneration 2011, 6:77 (17 November 2011)
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Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
Tomoko Konno, Saori Hata, Yukiko Hamada, Yuko Horikoshi-Sakuraba, Tadashi Nakaya, Yuhki Saito, Tohru Yamamoto, Takayuki Yamamoto, Masahiro Maeda, Takeshi Ikeuchi, Sam Gandy, Hiroyasu Akatsu, Toshiharu Suzuki, the Japanese Alzheimer's Disease Neuroimaging Initiative Molecular Neurodegeneration 2011, 6:76 (8 November 2011)
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Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis
Yi Wang, Yan Pan, Ann Price, Lee J Martin Molecular Neurodegeneration 2011, 6:75 (2 November 2011)
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Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity
Xavier Xifró, Marta Anglada-Huguet, Laura Rué, Ana Saavedra, Esther Pérez-Navarro, Jordi Alberch Molecular Neurodegeneration 2011, 6:74 (31 October 2011)
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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis, Leonard Petrucelli Molecular Neurodegeneration 2011, 6:73 (26 October 2011)
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Dopamine and α-synuclein dysfunction in Smad3 null mice
Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capelo Molecular Neurodegeneration 2011, 6:72 (13 October 2011)
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Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
Albert Giralt, Olga Carretón, Cristina Lao-Peregrin, Eduardo D Martín, Jordi Alberch Molecular Neurodegeneration 2011, 6:71 (10 October 2011)
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Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
Charlotte Delay, Frédéric Calon, Paul Mathews, Sébastien S Hébert Molecular Neurodegeneration 2011, 6:70 (7 October 2011)
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Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
Hong Jiang, Harald Hampel, David Prvulovic, Anders Wallin, Kaj Blennow, Rena Li, Yong Shen Molecular Neurodegeneration 2011, 6:69 (6 October 2011)
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Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo
Amandine Jullienne, Axel Montagne, Cyrille Orset, Flavie Lesept, David E Jane, Daniel T Monaghan, Eric Maubert, Denis Vivien, Carine Ali Molecular Neurodegeneration 2011, 6:68 (5 October 2011)
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Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
Leslie Crews, Rebecca Ruf, Christina Patrick, Wilmar Dumaop, Margarita Trejo-Morales, Cristian L Achim, Edward Rockenstein, Eliezer Masliah Molecular Neurodegeneration 2011, 6:67 (24 September 2011)
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Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease
Merav Kedmi, Anat Bar-Shira, Tanya Gurevich, Nir Giladi, Avi Orr-Urtreger Molecular Neurodegeneration 2011, 6:66 (23 September 2011)
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