|
|
|
|
|
|
Nurr1 regulates Top IIbeta and functions in axon genesis of mesencephalic dopaminergic neurons
Xin Heng, Gang Jin, Xin Zhang, Dehua Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le Molecular Neurodegeneration 2012, 7:4 (2 February 2012)
Abstract | Provisional PDF
|
|
|
|
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven Molecular Neurodegeneration 2012, 7:3 (16 January 2012)
Abstract | Provisional PDF
| PubMed
|
|
|
|
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen Molecular Neurodegeneration 2012, 7:2 (9 January 2012)
Abstract | Provisional PDF
| PubMed
|
|
|
|
Adeno-Associated Virus-Mediated Brain Delivery of 5-Lipoxygenase modulates the AD-like phenotype of APP mice
Jin Chu, Phillip F. Giannopoulos, Carolina Ceballos-Diaz, Todd E. Golde, Domenico Pratico Molecular Neurodegeneration 2012, 7:1 (5 January 2012)
Abstract | Provisional PDF
| PubMed
|
|
|
|
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.
|
|
|
|
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent, Gopal Thinakaran Molecular Neurodegeneration 2011, 6:87 (28 December 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Byung Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel Molecular Neurodegeneration 2011, 6:86 (22 December 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Microglial p38alpha MAPK is critical for LPS-induced neuron degeneration through a mechanism involving TNFalpha
Bin Xing, Adam D Bachstetter, Linda J Van Eldik Molecular Neurodegeneration 2011, 6:84 (20 December 2011)
Abstract | Provisional PDF
| PubMed
|
|
|
|
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet, Robert H Schiestl Molecular Neurodegeneration 2011, 6:83 (13 December 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
Yair M Gozal, Nicholas T Seyfried, Marla Gearing, Jonathan D Glass, Craig J Heilman, Joanne Wuu, Duc M Duong, Dongmei Cheng, Qiangwei Xia, Howard D Rees, Jason J Fritz, Deborah S Cooper, Junmin Peng, Allan I Levey, James J Lah Molecular Neurodegeneration 2011, 6:82 (29 November 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet, Ilya Bezprozvanny Molecular Neurodegeneration 2011, 6:81 (25 November 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Dantrolene, a RyanR inhibitor and calcium signalling stabilizer, is identified as a potential agent for the treatment of Huntingdons Disease, further implicating the disturbance of intracellular calcium signalling in the pathogenesis of polyglutamine expansion diseases.
|
|
|
|
Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes
Monique Judge, Lisa Hornbeck, Huntington Potter, Jaya Padmanabhan Molecular Neurodegeneration 2011, 6:80 (23 November 2011)
Abstract | Provisional PDF
| PubMed
|
|
|
|
Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
Xinyi Li, Joel N Buxbaum Molecular Neurodegeneration 2011, 6:79 (23 November 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp, Kurt F Hauser Molecular Neurodegeneration 2011, 6:78 (17 November 2011)
Abstract | Provisional PDF
| PubMed
|
|
|
|
Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
Mercedes Prudencio, David R Borchelt Molecular Neurodegeneration 2011, 6:77 (17 November 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
Tomoko Konno, Saori Hata, Yukiko Hamada, Yuko Horikoshi-Sakuraba, Tadashi Nakaya, Yuhki Saito, Tohru Yamamoto, Takayuki Yamamoto, Masahiro Maeda, Takeshi Ikeuchi, Sam Gandy, Hiroyasu Akatsu, Toshiharu Suzuki, the Japanese Alzheimer's Disease Neuroimaging Initiative Molecular Neurodegeneration 2011, 6:76 (8 November 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis
Yi Wang, Yan Pan, Ann Price, Lee J Martin Molecular Neurodegeneration 2011, 6:75 (2 November 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity
Xavier Xifró, Marta Anglada-Huguet, Laura Rué, Ana Saavedra, Esther Pérez-Navarro, Jordi Alberch Molecular Neurodegeneration 2011, 6:74 (31 October 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis, Leonard Petrucelli Molecular Neurodegeneration 2011, 6:73 (26 October 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Dopamine and α-synuclein dysfunction in Smad3 null mice
Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capelo Molecular Neurodegeneration 2011, 6:72 (13 October 2011)
Abstract | Full text | PDF | PubMed |
|
|
|
|
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
Albert Giralt, Olga Carretón, Cristina Lao-Peregrin, Eduardo D Martín, Jordi Alberch Molecular Neurodegeneration 2011, 6:71 (10 October 2011)
Abstract | Full text | PDF | PubMed | F1000 Medicine
|
|
|
|
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
Charlotte Delay, Frédéric Calon, Paul Mathews, Sébastien S Hébert Molecular Neurodegeneration 2011, 6:70 (7 October 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
Hong Jiang, Harald Hampel, David Prvulovic, Anders Wallin, Kaj Blennow, Rena Li, Yong Shen Molecular Neurodegeneration 2011, 6:69 (6 October 2011)
Abstract | Full text | PDF | PubMed
|
|
|
|
Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo
Amandine Jullienne, Axel Montagne, Cyrille Orset, Flavie Lesept, David E Jane, Daniel T Monaghan, Eric Maubert, Denis Vivien, Carine Ali Molecular Neurodegeneration 2011, 6:68 (5 October 2011)
Abstract | Full text | PDF | PubMed
|
