Molecular Neurodegeneration

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		Research article ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelson Molecular Neurodegeneration 2013, 8:16 (17 May 2013) Abstract \| Full text \| PDF
		Research article Normal cognition in transgenic BRI2-Aβ mice Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado Molecular Neurodegeneration 2013, 8:14 (26 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methodology In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methodology Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw Molecular Neurodegeneration 2013, 8:12 (8 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Reviewer acknowledgement Reviewer acknowledgement Guojun Bu, Huaxi Xu Molecular Neurodegeneration 2013, 8:11 (2 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methodology In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau _p301l) reveals reduced neural activity in memory formation structures Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara Molecular Neurodegeneration 2013, 8:9 (4 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Ceru', Sandra Moreno Molecular Neurodegeneration 2013, 8:8 (2 February 2013) Abstract \| Full text \| PDF \| PubMed
		Review HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet Molecular Neurodegeneration 2013, 8:7 (29 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett, Patricia A Trimmer Molecular Neurodegeneration 2013, 8:6 (26 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe Molecular Neurodegeneration 2013, 8:4 (18 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex Guo-Jun Chen, Zhe Xiong, Zhen Yan Molecular Neurodegeneration 2013, 8:3 (17 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ₄₂ accumulation and Caspase-3 activation William A Eimer, Robert Vassar Molecular Neurodegeneration 2013, 8:2 (14 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, Zuoshang Xu Molecular Neurodegeneration 2013, 8:1 (3 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka, Zhiming Tu, Faris Albayya, Winnie Lee, Sarah Hopp, Mary-Jo Miller, Darcie Spaulding, Zhiyong Yang, Hilliary Hodgdon, Scott Nolan, Melody Wen, Don Costa, Jean-Francois Blain, Emily Freeman, Bart De Strooper, Veerle Vulsteke, Louise Scrocchi, Henrik Zetterberg, Erik Portelius, Birgit Hutter-Paier, Daniel Havas, Michael Ahlijanian, Dorothy Flood, Liza Leventhal, Gideon Shapiro, Holger Patzke, Richard Chesworth, Gerhard Koenig et al. Molecular Neurodegeneration 2012, 7:61 (18 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection Robert Tamayev, Nsikan Akpan, Ottavio Arancio, Carol M Troy, Luciano D’Adamio Molecular Neurodegeneration 2012, 7:60 (10 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo, Victoria Navarro, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Irene Carmona, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica Molecular Neurodegeneration 2012, 7:59 (22 November 2012) Abstract \| Full text \| PDF \| PubMed
		Short report The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease Hannah Brautigam, John W Steele, David Westaway, Paul E Fraser, Peter H St George-Hyslop, Sam Gandy, Patrick R Hof, Dara L Dickstein Molecular Neurodegeneration 2012, 7:58 (22 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Utility of an improved model of amyloid-beta (Aβ_1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny Molecular Neurodegeneration 2012, 7:57 (21 November 2012) Abstract \| Full text \| PDF \| PubMed
		Review Regulated protein aggregation: stress granules and neurodegeneration Benjamin Wolozin Molecular Neurodegeneration 2012, 7:56 (20 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells Alexander Slowik, Julika Merres, Anne Elfgen, Sandra Jansen, Fabian Mohr, Christoph J Wruck, Thomas Pufe, Lars-Ove Brandenburg Molecular Neurodegeneration 2012, 7:55 (20 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde Molecular Neurodegeneration 2012, 7:54 (24 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis Christophe Verbeeck, Qiudong Deng, Mariely DeJesus-Hernandez, Georgia Taylor, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W Dickson, Thomas Kukar Molecular Neurodegeneration 2012, 7:53 (10 October 2012) Abstract \| Full text \| PDF \| PubMed

	All
		Research article ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelson Molecular Neurodegeneration 2013, 8:16 (17 May 2013) Abstract \| Full text \| PDF
		Research article Normal cognition in transgenic BRI2-Aβ mice Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado Molecular Neurodegeneration 2013, 8:14 (26 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methodology In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methodology Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw Molecular Neurodegeneration 2013, 8:12 (8 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Reviewer acknowledgement Reviewer acknowledgement Guojun Bu, Huaxi Xu Molecular Neurodegeneration 2013, 8:11 (2 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Methodology In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau _p301l) reveals reduced neural activity in memory formation structures Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara Molecular Neurodegeneration 2013, 8:9 (4 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Ceru', Sandra Moreno Molecular Neurodegeneration 2013, 8:8 (2 February 2013) Abstract \| Full text \| PDF \| PubMed
		Review HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet Molecular Neurodegeneration 2013, 8:7 (29 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett, Patricia A Trimmer Molecular Neurodegeneration 2013, 8:6 (26 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe Molecular Neurodegeneration 2013, 8:4 (18 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex Guo-Jun Chen, Zhe Xiong, Zhen Yan Molecular Neurodegeneration 2013, 8:3 (17 January 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
		Research article Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ₄₂ accumulation and Caspase-3 activation William A Eimer, Robert Vassar Molecular Neurodegeneration 2013, 8:2 (14 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, Zuoshang Xu Molecular Neurodegeneration 2013, 8:1 (3 January 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka, Zhiming Tu, Faris Albayya, Winnie Lee, Sarah Hopp, Mary-Jo Miller, Darcie Spaulding, Zhiyong Yang, Hilliary Hodgdon, Scott Nolan, Melody Wen, Don Costa, Jean-Francois Blain, Emily Freeman, Bart De Strooper, Veerle Vulsteke, Louise Scrocchi, Henrik Zetterberg, Erik Portelius, Birgit Hutter-Paier, Daniel Havas, Michael Ahlijanian, Dorothy Flood, Liza Leventhal, Gideon Shapiro, Holger Patzke, Richard Chesworth, Gerhard Koenig et al. Molecular Neurodegeneration 2012, 7:61 (18 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection Robert Tamayev, Nsikan Akpan, Ottavio Arancio, Carol M Troy, Luciano D’Adamio Molecular Neurodegeneration 2012, 7:60 (10 December 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo, Victoria Navarro, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Irene Carmona, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica Molecular Neurodegeneration 2012, 7:59 (22 November 2012) Abstract \| Full text \| PDF \| PubMed
		Short report The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease Hannah Brautigam, John W Steele, David Westaway, Paul E Fraser, Peter H St George-Hyslop, Sam Gandy, Patrick R Hof, Dara L Dickstein Molecular Neurodegeneration 2012, 7:58 (22 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Utility of an improved model of amyloid-beta (Aβ_1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny Molecular Neurodegeneration 2012, 7:57 (21 November 2012) Abstract \| Full text \| PDF \| PubMed
		Review Regulated protein aggregation: stress granules and neurodegeneration Benjamin Wolozin Molecular Neurodegeneration 2012, 7:56 (20 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells Alexander Slowik, Julika Merres, Anne Elfgen, Sandra Jansen, Fabian Mohr, Christoph J Wruck, Thomas Pufe, Lars-Ove Brandenburg Molecular Neurodegeneration 2012, 7:55 (20 November 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde Molecular Neurodegeneration 2012, 7:54 (24 October 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis Christophe Verbeeck, Qiudong Deng, Mariely DeJesus-Hernandez, Georgia Taylor, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W Dickson, Thomas Kukar Molecular Neurodegeneration 2012, 7:53 (10 October 2012) Abstract \| Full text \| PDF \| PubMed