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Inhibition of MMP-9 by a selective gelatinase
inhibitor protects neurovasculature from embolic
focal cerebral ischemia
Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun, Zezong Gu Molecular Neurodegeneration 2012, 7:21 (15 May 2012)
Abstract | Provisional PDF
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Quantitative connection between polyglutamine
aggregation kinetics and neurodegenerative process
in patients with Huntington's disease
Keizo Sugaya, Shiro Matsubara Molecular Neurodegeneration 2012, 7:20 (14 May 2012)
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Inhibition of gamma-secretase worsens memory deficits in
a genetically congruous mouse model of Danish
dementia
Robert Tamayev, Luciano D'Adamio Molecular Neurodegeneration 2012, 7:19 (26 April 2012)
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Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity
Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins Molecular Neurodegeneration 2012, 7:18 (26 April 2012)
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Apoptosis-inducing factor downregulation increased
neuronal progenitor, but not stem cell, survival in
the neonatal hippocampus after cerebral hypoxiaischemia
Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren, Changlian Zhu Molecular Neurodegeneration 2012, 7:17 (25 April 2012)
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Multiple gamma-secretase product peptides are
coordinately increased in concentration in the
cerebrospinal fluid of a subpopulation of sporadic
Alzheimer's disease subjects
Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki Molecular Neurodegeneration 2012, 7:16 (25 April 2012)
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The I2020T Leucine-rich repeat kinase 2 transgenic
mouse exhibits impaired locomotive ability
accompanied by dopaminergic neuron abnormalities
Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima, Sadahiro Azuma, Etsuro Ohta, Fumiya Obata Molecular Neurodegeneration 2012, 7:15 (25 April 2012)
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Measurement of apolipoprotein E and amyloid beta
clearance rates in the mouse brain using bolus stable
isotope labeling
Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman, David M Holtzman Molecular Neurodegeneration 2012, 7:14 (18 April 2012)
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Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
Mariet Allen, Fanggeng Zou, High Seng Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak, Sumit Middha, Sooraj Maharjan, Constantin Georgescu, Debra Schultz, Fariborz Rakhshan, Christopher P Kolbert, Jin Jen, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilufer Ertekin-Taner et al.
Molecular Neurodegeneration 2012, 7:13 (11 April 2012)
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Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine, Marie-Françoise Chesselet Molecular Neurodegeneration 2012, 7:12 (4 April 2012)
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Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andres Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo, Francisca C Bronfman Molecular Neurodegeneration 2012, 7:11 (29 March 2012)
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Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia Molecular Neurodegeneration 2012, 7:10 (24 March 2012)
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FE65 as a link between VLDLR and APP to regulate their trafficking and processing
Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guenette, Toshiharu Suzuki, Paul M. Mathews, Daniel T.S. Pak, G. WILLIAM Rebeck, Yoo-hun Suh, Hee-Sae Park, Hyang-Sook Hoe Molecular Neurodegeneration 2012, 7:9 (19 March 2012)
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Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley, Mary Jo LaDu Molecular Neurodegeneration 2012, 7:8 (16 March 2012)
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Rapid glutamate receptor 2 trafficking during retinal degeneration
Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc Molecular Neurodegeneration 2012, 7:7 (10 February 2012)
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Spinal cord trauma and the molecular point of no return
Ping K Yip, Andrea Malaspina Molecular Neurodegeneration 2012, 7:6 (8 February 2012)
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WldS
but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
Jo Ann V Antenor-Dorsey, Karen L O'Malley Molecular Neurodegeneration 2012, 7:5 (8 February 2012)
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Nurr1 regulates Top IIbeta and functions in axon genesis of mesencephalic dopaminergic neurons
Xin Heng, Gang Jin, Xin Zhang, Dehua Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le Molecular Neurodegeneration 2012, 7:4 (2 February 2012)
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Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven Molecular Neurodegeneration 2012, 7:3 (16 January 2012)
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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen Molecular Neurodegeneration 2012, 7:2 (9 January 2012)
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Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde, Domenico Pratico Molecular Neurodegeneration 2012, 7:1 (5 January 2012)
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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)
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Editor’s summary
BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.
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Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent, Gopal Thinakaran Molecular Neurodegeneration 2011, 6:87 (28 December 2011)
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Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Byung Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel Molecular Neurodegeneration 2011, 6:86 (22 December 2011)
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Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)
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