Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.

Regulated cleavage of the Alzheimer amyloid precursor protein: molecular and cellular basis.

Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.

Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.

Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme.

New players in old amyloid precursor protein-processing pathways.

Expression cloning screen for modifiers of amyloid precursor protein shedding.

Role of the juxtamembrane domains of the transforming growth factor-alpha precursor and the beta-amyloid precursor protein in regulated ectodomain shedding.

Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx.

P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).