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Cole SL, Vassar R.
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The Alzheimer's disease beta-secretase enzyme, BACE1.
Mol Neurodegener. 2007 Nov 15;2:22.
PMID: 18005427 [PubMed - in process]
2:
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Cole SL, Vassar R.
Abstract
BACE1 structure and function in health and Alzheimer's disease.
Curr Alzheimer Res. 2008 Apr;5(2):100-20. Review.
PMID: 18393796 [PubMed - indexed for MEDLINE]
3:
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Vassar R.
Abstract
beta-Secretase, APP and Abeta in Alzheimer's disease.
Subcell Biochem. 2005;38:79-103. Review.
PMID: 15709474 [PubMed - indexed for MEDLINE]
4:
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Vassar R.
Abstract
Beta-secretase (BACE) as a drug target for Alzheimer's disease.
Adv Drug Deliv Rev. 2002 Dec 7;54(12):1589-602. Review.
PMID: 12453676 [PubMed - indexed for MEDLINE]
5:
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Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.
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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
J Neurosci. 2007 Apr 4;27(14):3639-49.
PMID: 17409228 [PubMed - indexed for MEDLINE]
6:
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Cole SL, Vassar R.
Abstract
Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1.
Neurobiol Aging. 2008 Feb 18. [Epub ahead of print]
PMID: 18289733 [PubMed - as supplied by publisher]
7:
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Velliquette RA, O'Connor T, Vassar R.
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Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.
J Neurosci. 2005 Nov 23;25(47):10874-83. Erratum in: J Neurosci. 2006 Feb 15;26(7):2140-2.
PMID: 16306400 [PubMed - indexed for MEDLINE]
8:
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Cole SL, Vassar R.
Abstract
The Role of Amyloid Precursor Protein Processing by BACE1, the {beta}-Secretase, in Alzheimer Disease Pathophysiology.
J Biol Chem. 2008 Oct 31;283(44):29621-5. Epub 2008 Jul 23.
PMID: 18650431 [PubMed - in process]
9:
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Luo Y, Bolon B, Damore MA, Fitzpatrick D, Liu H, Zhang J, Yan Q, Vassar R, Citron M.
Abstract
BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time.
Neurobiol Dis. 2003 Oct;14(1):81-8.
PMID: 13678669 [PubMed - indexed for MEDLINE]
10:
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Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF.
Abstract
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Neuron. 2004 Jan 8;41(1):27-33.
PMID: 14715132 [PubMed - indexed for MEDLINE]
11:
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Hampel H, Shen Y.
Abstract
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.
Scand J Clin Lab Invest. 2008 Apr 9:1-5. [Epub ahead of print]
PMID: 18609117 [PubMed - as supplied by publisher]
12:
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Rossner S, Lange-Dohna C, Zeitschel U, Perez-Polo JR.
Abstract
Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme.
J Neurochem. 2005 Jan;92(2):226-34. Review.
PMID: 15663471 [PubMed - indexed for MEDLINE]
13:
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Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT.
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Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
J Biol Chem. 2004 Dec 10;279(50):52535-42. Epub 2004 Sep 27.
PMID: 15452128 [PubMed - indexed for MEDLINE]
14:
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Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.
Abstract
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
Eur J Neurosci. 2006 Jan;23(1):251-60.
PMID: 16420434 [PubMed - indexed for MEDLINE]
15:
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Scholefield Z, Yates EA, Wayne G, Amour A, McDowell W, Turnbull JE.
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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
J Cell Biol. 2003 Oct 13;163(1):97-107. Epub 2003 Oct 6.
PMID: 14530380 [PubMed - indexed for MEDLINE]
16:
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Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.
Abstract
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
J Neurochem. 2006 Dec;99(6):1555-63. Epub 2006 Nov 2.
PMID: 17083447 [PubMed - indexed for MEDLINE]
17:
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Hartlage-Rübsamen M, Zeitschel U, Apelt J, Gärtner U, Franke H, Stahl T, Günther A, Schliebs R, Penkowa M, Bigl V, Rossner S.
Abstract
Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.
Glia. 2003 Jan 15;41(2):169-79.
PMID: 12509807 [PubMed - indexed for MEDLINE]
18:
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Rossner S, Sastre M, Bourne K, Lichtenthaler SF.
Abstract
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14. Review.
PMID: 16904810 [PubMed - indexed for MEDLINE]
19:
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Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.
Abstract
Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80.
PMID: 15851852 [PubMed - indexed for MEDLINE]
20:
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Liu K, Solano I, Mann D, Lemere C, Mercken M, Trojanowski JQ, Lee VM.
Abstract
Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
Acta Neuropathol. 2006 Aug;112(2):163-74. Epub 2006 Jun 1.
PMID: 16865398 [PubMed - indexed for MEDLINE]
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