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Gu X, André VM, Cepeda C, Li SH, Li XJ, Levine MS, Yang XW.
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Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease.
Mol Neurodegener. 2007 Apr 30;2:8.
PMID: 17470275 [PubMed]
2:
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Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW.
Abstract
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.
Neuron. 2005 May 5;46(3):433-44.
PMID: 15882643 [PubMed - indexed for MEDLINE]
3:
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Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW.
Abstract
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
J Neurosci. 2008 Jun 11;28(24):6182-95.
PMID: 18550760 [PubMed - indexed for MEDLINE]
4:
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Fan MM, Fernandes HB, Zhang LY, Hayden MR, Raymond LA.
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Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.
J Neurosci. 2007 Apr 4;27(14):3768-79.
PMID: 17409241 [PubMed - indexed for MEDLINE]
5:
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Starling AJ, André VM, Cepeda C, de Lima M, Chandler SH, Levine MS.
Abstract
Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease.
J Neurosci Res. 2005 Nov 1;82(3):377-86.
PMID: 16211559 [PubMed - indexed for MEDLINE]
6:
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Fernandes HB, Baimbridge KG, Church J, Hayden MR, Raymond LA.
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Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.
J Neurosci. 2007 Dec 12;27(50):13614-23.
PMID: 18077673 [PubMed - indexed for MEDLINE]
7:
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Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.
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Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.
Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.
PMID: 10434303 [PubMed - indexed for MEDLINE]
8:
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Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.
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Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Cell Death Differ. 2004 Apr;11(4):424-38.
PMID: 14713958 [PubMed - indexed for MEDLINE]
9:
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Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR.
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Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.
J Neurosci. 2007 Oct 24;27(43):11758-68.
PMID: 17959817 [PubMed - indexed for MEDLINE]
10:
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Estrada Sánchez AM, Mejía-Toiber J, Massieu L.
Abstract
Excitotoxic neuronal death and the pathogenesis of Huntington's disease.
Arch Med Res. 2008 Apr;39(3):265-76. Review.
PMID: 18279698 [PubMed - indexed for MEDLINE]
11:
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Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA.
Abstract
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease.
Neuron. 2002 Mar 14;33(6):849-60.
PMID: 11906693 [PubMed - indexed for MEDLINE]
12:
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Li L, Murphy TH, Hayden MR, Raymond LA.
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Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease.
J Neurophysiol. 2004 Nov;92(5):2738-46. Epub 2004 Jul 7.
PMID: 15240759 [PubMed - indexed for MEDLINE]
13:
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Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ.
Abstract
Huntington aggregates may not predict neuronal death in Huntington's disease.
Ann Neurol. 1999 Dec;46(6):842-9.
PMID: 10589536 [PubMed - indexed for MEDLINE]
14:
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Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA.
Abstract
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.
Neurobiol Aging. 2003 Dec;24(8):1113-21.
PMID: 14643383 [PubMed - indexed for MEDLINE]
15:
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Tang TS, Chen X, Liu J, Bezprozvanny I.
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Dopaminergic signaling and striatal neurodegeneration in Huntington's disease.
J Neurosci. 2007 Jul 25;27(30):7899-910.
PMID: 17652581 [PubMed - indexed for MEDLINE]
16:
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Seong IS, Ivanova E, Lee JM, Choo YS, Fossale E, Anderson M, Gusella JF, Laramie JM, Myers RH, Lesort M, MacDonald ME.
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HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
Hum Mol Genet. 2005 Oct 1;14(19):2871-80. Epub 2005 Aug 22.
PMID: 16115812 [PubMed - indexed for MEDLINE]
17:
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Li H, Li SH, Yu ZX, Shelbourne P, Li XJ.
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Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.
J Neurosci. 2001 Nov 1;21(21):8473-81.
PMID: 11606636 [PubMed - indexed for MEDLINE]
18:
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Levine MS, Klapstein GJ, Koppel A, Gruen E, Cepeda C, Vargas ME, Jokel ES, Carpenter EM, Zanjani H, Hurst RS, Efstratiadis A, Zeitlin S, Chesselet MF.
Abstract
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease.
J Neurosci Res. 1999 Nov 15;58(4):515-32.
PMID: 10533044 [PubMed - indexed for MEDLINE]
19:
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Cowan CM, Raymond LA.
Abstract
Selective neuronal degeneration in Huntington's disease.
Curr Top Dev Biol. 2006;75:25-71. Review.
PMID: 16984809 [PubMed - indexed for MEDLINE]
20:
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Garcia M, Charvin D, Caboche J.
Abstract
Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture.
Neuroscience. 2004;127(4):859-70.
PMID: 15312898 [PubMed - indexed for MEDLINE]
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