Multiple pathways contribute to the pathogenesis of Huntington disease.

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Selective degeneration in YAC mouse models of Huntington disease.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Recent insights into the molecular pathogenesis of Huntington disease.

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.

Huntingtin and its role in neuronal degeneration.

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Selective neuronal degeneration in Huntington's disease.

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

[Huntington disease. A review]

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.

Context-dependent dysregulation of transcription by mutant huntingtin.

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease.

Aggregation in Huntington's disease: insights through modelling.

Global changes to the ubiquitin system in Huntington's disease.