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1: J Neural Transm. 2007;114(6):801-5. Epub 2007 Apr 10.
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Modification of L-DOPA pharmacological activity by MAO inhibitors.

Finberg JP, Sader-Mazbar O.

Pharmacology Department, Rappaport Faculty of Medicine, Technion, Haifa, Israel. finberg@tx.technion.ac.il

Dopamine behaves mainly as a MAO-A substrate in rodent brain, but selective inhibition of MAO-B results in an increased turning activity following L-DOPA administration in hemi-Parkinsonian rodents. Unilateral substantia nigra dopaminergic denervation results in serotonergic hyper-innervation which may increase the contribution of MAO-A in the denervated striatum. Possibly as a result of this, there was no change in striatal MAO-A activity when 95% of dopaminergic innervation was reduced by 6-hydroxydopamine, as assessed by apomorphine-induced turning activity. MAO-B as well as MAO-A may contribute to deamination of dopamine produced from L-DOPA.

PMID: 17417741 [PubMed - indexed for MEDLINE]