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1.

769
Accesses

Review   Open Access Highly Accessed

α-Synuclein and neuronal cell death

Mark R Cookson Molecular Neurodegeneration 2009, 4:9 (4 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

742
Accesses

Review   Open Access Highly Accessed

The Alzheimer's disease β-secretase enzyme, BACE1

Sarah L Cole, Robert Vassar Molecular Neurodegeneration 2007, 2:22 (15 November 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

717
Accesses

Methodology   Open Access

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

662
Accesses

Review   Open Access Highly Accessed

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet Molecular Neurodegeneration 2013, 8:7 (29 January 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

657
Accesses

Review   Open Access Highly Accessed

Regulated protein aggregation: stress granules and neurodegeneration

Benjamin Wolozin Molecular Neurodegeneration 2012, 7:56 (20 November 2012)

Abstract | Full text | PDF | PubMed

6.

639
Accesses

Review   Open Access Highly Accessed

Adult hippocampal neurogenesis and its role in Alzheimer's disease

Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)

Abstract | Full text | PDF | PubMed

7.

634
Accesses

Methodology   Open Access Highly Accessed

Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw Molecular Neurodegeneration 2013, 8:12 (8 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

622
Accesses

Research article   Open Access

Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits

Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado Molecular Neurodegeneration 2013, 8:14 (26 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

573
Accesses

Review   Open Access Highly Accessed

The amyloid precursor protein: beyond amyloid

Hui Zheng, Edward H Koo Molecular Neurodegeneration 2006, 1:5 (3 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

564
Accesses

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Alzheimer's disease: synaptic dysfunction and Aβ

Ganesh M Shankar, Dominic M Walsh Molecular Neurodegeneration 2009, 4:48 (23 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

484
Accesses

Research article   Open Access

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013)

Abstract | Full text | PDF | PubMed

12.

444
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Biology and pathophysiology of the amyloid precursor protein

Hui Zheng, Edward H Koo Molecular Neurodegeneration 2011, 6:27 (28 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

442
Accesses

Research article   Open Access Highly Accessed

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

William A Eimer, Robert Vassar Molecular Neurodegeneration 2013, 8:2 (14 January 2013)

Abstract | Full text | PDF | PubMed

14.

432
Accesses

Research article   Open Access Highly Accessed

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg, Pamela J McLean Molecular Neurodegeneration 2012, 7:42 (24 August 2012)

Abstract | Full text | PDF | PubMed

15.

428
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Does neuroinflammation fan the flame in neurodegenerative diseases?

Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine, Malú G Tansey Molecular Neurodegeneration 2009, 4:47 (16 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

428
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Review   Open Access Highly Accessed

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

Trent M Woodruff, John Thundyil, Sung-Chun Tang, Christopher G Sobey, Stephen M Taylor, Thiruma V Arumugam Molecular Neurodegeneration 2011, 6:11 (25 January 2011)

Abstract | Full text | PDF | PubMed

17.

413
Accesses

Research article   Open Access

Normal cognition in transgenic BRI2-Aβ mice

Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013)

Abstract | Full text | PDF | PubMed

18.

402
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Review   Open Access Highly Accessed

The role of tau in neurodegeneration

Tania F Gendron, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:13 (11 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

384
Accesses

Research article   Open Access

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease

Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Ceru', Sandra Moreno Molecular Neurodegeneration 2013, 8:8 (2 February 2013)

Abstract | Full text | PDF | PubMed

20.

381
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Research article   Open Access Highly Accessed

Identification of BACE2 as an avid ß-amyloid-degrading protease

Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring Molecular Neurodegeneration 2012, 7:46 (17 September 2012)

Abstract | Full text | PDF | PubMed

21.

375
Accesses

Review   Open Access Highly Accessed

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Philipp A Jaeger, Tony Wyss-Coray Molecular Neurodegeneration 2009, 4:16 (6 April 2009)

Abstract | Full text | PDF | PubMed

22.

370
Accesses

Review   Open Access Highly Accessed

Microglia in the aging brain: relevance to neurodegeneration

Xiao-Guang Luo, Jian-Qing Ding, Sheng-Di Chen Molecular Neurodegeneration 2010, 5:12 (24 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

337
Accesses

Research article   Open Access

Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression

Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett, Patricia A Trimmer Molecular Neurodegeneration 2013, 8:6 (26 January 2013)

Abstract | Full text | PDF | PubMed

24.

333
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Review   Open Access Highly Accessed

Tau exon 10 alternative splicing and tauopathies

Fei Liu, Cheng-Xin Gong Molecular Neurodegeneration 2008, 3:8 (10 July 2008)

Abstract | Full text | PDF | PubMed

25.

324
Accesses

Research article   Open Access

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

26.

317
Accesses

Review   Open Access Highly Accessed

Calcium signaling in neurodegeneration

Philippe Marambaud, Ute Dreses-Werringloer, Valérie Vingtdeux Molecular Neurodegeneration 2009, 4:20 (6 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

309
Accesses

Methodology   Open Access

In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau p301l) reveals reduced neural activity in memory formation structures

Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara Molecular Neurodegeneration 2013, 8:9 (4 February 2013)

Abstract | Full text | PDF | PubMed

28.

307
Accesses

Review   Open Access Highly Accessed

Does a loss of TDP-43 function cause neurodegeneration?

Zuo-Shang Xu Molecular Neurodegeneration 2012, 7:27 (14 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

305
Accesses

Research article   Open Access Highly Accessed

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

Xiao-dong Pan, Yuan-gui Zhu, Nan Lin, Jing Zhang, Qin-yong Ye, Hua-pin Huang, Xiao-chun Chen Molecular Neurodegeneration 2011, 6:45 (30 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

304
Accesses

Research article   Open Access

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelson Molecular Neurodegeneration 2013, 8:16 (17 May 2013)

Abstract | Full text | PDF | PubMed

31.

293
Accesses

Research article   Open Access Highly Accessed

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Subbiah Pugazhenthi, Maorong Wang, Serena Pham, Chun-I Sze, Christopher B Eckman Molecular Neurodegeneration 2011, 6:60 (19 August 2011)

Abstract | Full text | PDF | PubMed

32.

292
Accesses

Research article   Open Access Highly Accessed

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Rakez Kayed, Elizabeth Head, Floyd Sarsoza, Tommy Saing, Carl W Cotman, Mihaela Necula, Lawrence Margol, Jessica Wu, Leonid Breydo, Jennifer L Thompson, Suhail Rasool, Tatyana Gurlo, Peter Butler, Charles G Glabe Molecular Neurodegeneration 2007, 2:18 (26 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

283
Accesses

Review   Open Access Highly Accessed

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

Kristen A Malkus, Elpida Tsika, Harry Ischiropoulos Molecular Neurodegeneration 2009, 4:24 (5 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

282
Accesses

Review   Open Access Highly Accessed

Alzheimer's disease: synapses gone cold

Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones Molecular Neurodegeneration 2011, 6:63 (26 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

274
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Heat shock protein 90 in neurodegenerative diseases

Wenjie Luo, Weilin Sun, Tony Taldone, Anna Rodina, Gabriela Chiosis Molecular Neurodegeneration 2010, 5:24 (3 June 2010)

Abstract | Full text | PDF | PubMed

36.

267
Accesses

Research article   Open Access

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny Molecular Neurodegeneration 2012, 7:57 (21 November 2012)

Abstract | Full text | PDF | PubMed

37.

256
Accesses

Research article   Open Access Highly Accessed

Regulation of mitochondrial permeability transition pore by PINK1

Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Núñez, Zhiyin Song, David Chan, Carlos Villalobos, Jie Shen Molecular Neurodegeneration 2012, 7:22 (25 May 2012)

Abstract | Full text | PDF | PubMed

38.

255
Accesses

Research article   Open Access Highly Accessed

6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death

Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malley Molecular Neurodegeneration 2011, 6:2 (6 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

248
Accesses

Research article   Open Access

Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma

Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe Molecular Neurodegeneration 2013, 8:4 (18 January 2013)

Abstract | Full text | PDF | PubMed

40.

240
Accesses

Review   Open Access

Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease

Lonnie Schneider, Jianhua Zhang Molecular Neurodegeneration 2010, 5:14 (13 April 2010)

Abstract | Full text | PDF | PubMed

41.

239
Accesses

Methodology   Open Access Highly Accessed

High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function

Claudia Fallini, Gary J Bassell, Wilfried Rossoll Molecular Neurodegeneration 2010, 5:17 (21 April 2010)

Abstract | Full text | PDF | PubMed

42.

239
Accesses

Research article   Open Access

Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells

Alexander Slowik, Julika Merres, Anne Elfgen, Sandra Jansen, Fabian Mohr, Christoph J Wruck, Thomas Pufe, Lars-Ove Brandenburg Molecular Neurodegeneration 2012, 7:55 (20 November 2012)

Abstract | Full text | PDF | PubMed

43.

237
Accesses

Reviewer acknowledgement   Open Access

Reviewer acknowledgement

Guojun Bu, Huaxi Xu Molecular Neurodegeneration 2013, 8:11 (2 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

44.

227
Accesses

Research article   Open Access Highly Accessed

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson, Rakez Kayed Molecular Neurodegeneration 2011, 6:39 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

224
Accesses

Research article   Open Access Highly Accessed

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany Dugger, Beate Winner, Iryna Prots, Caroline B Kent, Kenya Nishioka, Wen-Lang Lin, Dennis W Dickson, Christopher J Janus, Matthew J Farrer, Heather L Melrose Molecular Neurodegeneration 2012, 7:25 (30 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

LRRK2 knockout mice have a normal dopaminergic system and do not develop any pathological features of Parkinsons disease, but they do display altered exploratory and motor co-ordination behaviors, and degeneration in the kidney.

46.

221
Accesses

Review   Open Access

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease

Todd E Golde Molecular Neurodegeneration 2009, 4:8 (4 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

220
Accesses

Research article   Open Access Highly Accessed

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling

Ethan A Winkler, Robert D Bell, Berislav V Zlokovic Molecular Neurodegeneration 2010, 5:32 (25 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

220
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Research article   Open Access

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

Andreas M Grabrucker, Michael J Schmeisser, Patrick T Udvardi, Magali Arons, Michael Schoen, Nathaniel S Woodling, Katrin I Andreasson, Patrick R Hof, Joseph D Buxbaum, Craig C Garner, Tobias M Boeckers Molecular Neurodegeneration 2011, 6:65 (22 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

49.

218
Accesses

Research article   Open Access

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

Sandra I Vieira, Sandra Rebelo, Hermann Esselmann, Jens Wiltfang, James Lah, Rachel Lane, Scott A Small, Sam Gandy, Edgar F da Cruz e Silva, Odete AB da Cruz e Silva Molecular Neurodegeneration 2010, 5:40 (11 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

219
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Research article   Open Access Highly Accessed

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

Fanjun Meng, Dongdong Yao, Yang Shi, Jonathan Kabakoff, Wei Wu, Joshua Reicher, Yuliang Ma, Bernd Moosmann, Eliezer Masliah, Stuart A Lipton, Zezong Gu Molecular Neurodegeneration 2011, 6:34 (19 May 2011)

Abstract | Full text | PDF | PubMed

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