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1.
769 Accesses
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α-Synuclein and neuronal cell death
Mark R Cookson Molecular Neurodegeneration 2009, 4:9 (4 February 2009)
Abstract | Full text | PDF
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2.
742 Accesses
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The Alzheimer's disease β-secretase enzyme, BACE1
Sarah L Cole, Robert Vassar Molecular Neurodegeneration 2007, 2:22 (15 November 2007)
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3.
717 Accesses
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In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013)
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4.
662 Accesses
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HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet Molecular Neurodegeneration 2013, 8:7 (29 January 2013)
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5.
657 Accesses
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Regulated protein aggregation: stress granules and neurodegeneration
Benjamin Wolozin Molecular Neurodegeneration 2012, 7:56 (20 November 2012)
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6.
639 Accesses
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Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)
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7.
634 Accesses
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Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw Molecular Neurodegeneration 2013, 8:12 (8 April 2013)
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8.
622 Accesses
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Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado Molecular Neurodegeneration 2013, 8:14 (26 April 2013)
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9.
573 Accesses
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The amyloid precursor protein: beyond amyloid
Hui Zheng, Edward H Koo Molecular Neurodegeneration 2006, 1:5 (3 July 2006)
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10.
564 Accesses
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Alzheimer's disease: synaptic dysfunction and Aβ
Ganesh M Shankar, Dominic M Walsh Molecular Neurodegeneration 2009, 4:48 (23 November 2009)
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11.
484 Accesses
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Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013)
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12.
444 Accesses
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Biology and pathophysiology of the amyloid precursor protein
Hui Zheng, Edward H Koo Molecular Neurodegeneration 2011, 6:27 (28 April 2011)
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13.
442 Accesses
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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
William A Eimer, Robert Vassar Molecular Neurodegeneration 2013, 8:2 (14 January 2013)
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14.
432 Accesses
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Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg, Pamela J McLean Molecular Neurodegeneration 2012, 7:42 (24 August 2012)
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15.
428 Accesses
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Does neuroinflammation fan the flame in neurodegenerative diseases?
Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine, Malú G Tansey Molecular Neurodegeneration 2009, 4:47 (16 November 2009)
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16.
428 Accesses
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Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
Trent M Woodruff, John Thundyil, Sung-Chun Tang, Christopher G Sobey, Stephen M Taylor, Thiruma V Arumugam Molecular Neurodegeneration 2011, 6:11 (25 January 2011)
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17.
413 Accesses
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Normal cognition in transgenic BRI2-Aβ mice
Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013)
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18.
402 Accesses
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The role of tau in neurodegeneration
Tania F Gendron, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:13 (11 March 2009)
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19.
384 Accesses
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Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Ceru', Sandra Moreno Molecular Neurodegeneration 2013, 8:8 (2 February 2013)
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20.
381 Accesses
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Identification of BACE2 as an avid ß-amyloid-degrading protease
Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring Molecular Neurodegeneration 2012, 7:46 (17 September 2012)
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21.
375 Accesses
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All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Philipp A Jaeger, Tony Wyss-Coray Molecular Neurodegeneration 2009, 4:16 (6 April 2009)
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22.
370 Accesses
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Microglia in the aging brain: relevance to neurodegeneration
Xiao-Guang Luo, Jian-Qing Ding, Sheng-Di Chen Molecular Neurodegeneration 2010, 5:12 (24 March 2010)
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23.
337 Accesses
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Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression
Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett, Patricia A Trimmer Molecular Neurodegeneration 2013, 8:6 (26 January 2013)
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24.
333 Accesses
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Tau exon 10 alternative splicing and tauopathies
Fei Liu, Cheng-Xin Gong Molecular Neurodegeneration 2008, 3:8 (10 July 2008)
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25.
324 Accesses
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Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013)
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26.
317 Accesses
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Calcium signaling in neurodegeneration
Philippe Marambaud, Ute Dreses-Werringloer, Valérie Vingtdeux Molecular Neurodegeneration 2009, 4:20 (6 May 2009)
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27.
309 Accesses
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In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau
p301l) reveals reduced neural activity in memory formation structures
Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara Molecular Neurodegeneration 2013, 8:9 (4 February 2013)
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28.
307 Accesses
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Does a loss of TDP-43 function cause neurodegeneration?
Zuo-Shang Xu Molecular Neurodegeneration 2012, 7:27 (14 June 2012)
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29.
305 Accesses
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Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
Xiao-dong Pan, Yuan-gui Zhu, Nan Lin, Jing Zhang, Qin-yong Ye, Hua-pin Huang, Xiao-chun Chen Molecular Neurodegeneration 2011, 6:45 (30 June 2011)
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30.
304 Accesses
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ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelson Molecular Neurodegeneration 2013, 8:16 (17 May 2013)
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31.
293 Accesses
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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
Subbiah Pugazhenthi, Maorong Wang, Serena Pham, Chun-I Sze, Christopher B Eckman Molecular Neurodegeneration 2011, 6:60 (19 August 2011)
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32.
292 Accesses
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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
Rakez Kayed, Elizabeth Head, Floyd Sarsoza, Tommy Saing, Carl W Cotman, Mihaela Necula, Lawrence Margol, Jessica Wu, Leonid Breydo, Jennifer L Thompson, Suhail Rasool, Tatyana Gurlo, Peter Butler, Charles G Glabe Molecular Neurodegeneration 2007, 2:18 (26 September 2007)
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33.
283 Accesses
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Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle
Kristen A Malkus, Elpida Tsika, Harry Ischiropoulos Molecular Neurodegeneration 2009, 4:24 (5 June 2009)
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34.
282 Accesses
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Alzheimer's disease: synapses gone cold
Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones Molecular Neurodegeneration 2011, 6:63 (26 August 2011)
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35.
274 Accesses
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Heat shock protein 90 in neurodegenerative diseases
Wenjie Luo, Weilin Sun, Tony Taldone, Anna Rodina, Gabriela Chiosis Molecular Neurodegeneration 2010, 5:24 (3 June 2010)
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36.
267 Accesses
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Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease
Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny Molecular Neurodegeneration 2012, 7:57 (21 November 2012)
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37.
256 Accesses
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Regulation of mitochondrial permeability transition pore by PINK1
Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Núñez, Zhiyin Song, David Chan, Carlos Villalobos, Jie Shen Molecular Neurodegeneration 2012, 7:22 (25 May 2012)
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38.
255 Accesses
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6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malley Molecular Neurodegeneration 2011, 6:2 (6 January 2011)
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39.
248 Accesses
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Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma
Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe Molecular Neurodegeneration 2013, 8:4 (18 January 2013)
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40.
240 Accesses
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Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease
Lonnie Schneider, Jianhua Zhang Molecular Neurodegeneration 2010, 5:14 (13 April 2010)
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41.
239 Accesses
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High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function
Claudia Fallini, Gary J Bassell, Wilfried Rossoll Molecular Neurodegeneration 2010, 5:17 (21 April 2010)
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42.
239 Accesses
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Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
Alexander Slowik, Julika Merres, Anne Elfgen, Sandra Jansen, Fabian Mohr, Christoph J Wruck, Thomas Pufe, Lars-Ove Brandenburg Molecular Neurodegeneration 2012, 7:55 (20 November 2012)
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43.
237 Accesses
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Reviewer acknowledgement
Guojun Bu, Huaxi Xu Molecular Neurodegeneration 2013, 8:11 (2 April 2013)
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44.
227 Accesses
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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson, Rakez Kayed Molecular Neurodegeneration 2011, 6:39 (6 June 2011)
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45.
224 Accesses
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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany Dugger, Beate Winner, Iryna Prots, Caroline B Kent, Kenya Nishioka, Wen-Lang Lin, Dennis W Dickson, Christopher J Janus, Matthew J Farrer, Heather L Melrose Molecular Neurodegeneration 2012, 7:25 (30 May 2012)
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Editor’s summary
LRRK2 knockout mice have a normal dopaminergic system and do not develop any pathological features of Parkinsons disease, but they do display altered exploratory and motor co-ordination behaviors, and degeneration in the kidney.
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46.
221 Accesses
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The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
Todd E Golde Molecular Neurodegeneration 2009, 4:8 (4 February 2009)
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47.
220 Accesses
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Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
Ethan A Winkler, Robert D Bell, Berislav V Zlokovic Molecular Neurodegeneration 2010, 5:32 (25 August 2010)
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48.
220 Accesses
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Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
Andreas M Grabrucker, Michael J Schmeisser, Patrick T Udvardi, Magali Arons, Michael Schoen, Nathaniel S Woodling, Katrin I Andreasson, Patrick R Hof, Joseph D Buxbaum, Craig C Garner, Tobias M Boeckers Molecular Neurodegeneration 2011, 6:65 (22 September 2011)
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49.
218 Accesses
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Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
Sandra I Vieira, Sandra Rebelo, Hermann Esselmann, Jens Wiltfang, James Lah, Rachel Lane, Scott A Small, Sam Gandy, Edgar F da Cruz e Silva, Odete AB da Cruz e Silva Molecular Neurodegeneration 2010, 5:40 (11 October 2010)
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50.
219 Accesses
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Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
Fanjun Meng, Dongdong Yao, Yang Shi, Jonathan Kabakoff, Wei Wu, Joshua Reicher, Yuliang Ma, Bernd Moosmann, Eliezer Masliah, Stuart A Lipton, Zezong Gu Molecular Neurodegeneration 2011, 6:34 (19 May 2011)
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