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76.

179
Accesses

Research article   Open Access Highly Accessed

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde Molecular Neurodegeneration 2012, 7:54 (24 October 2012)

Abstract | Full text | PDF | PubMed

77.

178
Accesses

Research article   Open Access Highly Accessed

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba, Nobuyuki Nukina Molecular Neurodegeneration 2012, 7:43 (28 August 2012)

Abstract | Full text | PDF | PubMed

78.

177
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Review   Open Access Highly Accessed

Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Judy A Cam, Guojun Bu Molecular Neurodegeneration 2006, 1:8 (18 August 2006)

Abstract | Full text | PDF | PubMed

79.

175
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Research article   Open Access

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

Terina N Martinez, Xi Chen, Sibali Bandyopadhyay, Alfred H Merrill, Malú G Tansey Molecular Neurodegeneration 2012, 7:45 (13 September 2012)

Abstract | Full text | PDF | PubMed

80.

174
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Research article   Open Access Highly Accessed

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

Bin Xing, Adam D Bachstetter, Linda J Van Eldik Molecular Neurodegeneration 2011, 6:84 (20 December 2011)

Abstract | Full text | PDF | PubMed

81.

174
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Research article   Open Access

Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

Guo-Jun Chen, Zhe Xiong, Zhen Yan Molecular Neurodegeneration 2013, 8:3 (17 January 2013)

Abstract | Full text | PDF | ePUB | PubMed

82.

173
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Review   Open Access Highly Accessed

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Nibaldo C Inestrosa, Enrique M Toledo Molecular Neurodegeneration 2008, 3:9 (24 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

83.

173
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Research article   Open Access

Effects of chronic low dose rotenone treatment on human microglial cells

Shamim B Shaikh, Louise FB Nicholson Molecular Neurodegeneration 2009, 4:55 (31 December 2009)

Abstract | Full text | PDF | PubMed

84.

171
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Review   Open Access Highly Accessed

The generation and function of soluble apoE receptors in the CNS

G William Rebeck, Mary LaDu, Steven Estus, Guojun Bu, Edwin J Weeber Molecular Neurodegeneration 2006, 1:15 (24 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

85.

170
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Review   Open Access Highly Accessed

Pathological and physiological functions of presenilins

Kulandaivelu S Vetrivel, Yun-wu Zhang, Huaxi Xu, Gopal Thinakaran Molecular Neurodegeneration 2006, 1:4 (12 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

86.

171
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Research article   Open Access Highly Accessed

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.

87.

164
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Research article   Open Access Highly Accessed

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

Richard C Davis, Ian T Marsden, Michael T Maloney, Laurie S Minamide, Marcia Podlisny, Dennis J Selkoe, James R Bamburg Molecular Neurodegeneration 2011, 6:10 (24 January 2011)

Abstract | Full text | PDF | PubMed

88.

167
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Research article   Open Access

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

Christophe Verbeeck, Qiudong Deng, Mariely DeJesus-Hernandez, Georgia Taylor, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W Dickson, Thomas Kukar Molecular Neurodegeneration 2012, 7:53 (10 October 2012)

Abstract | Full text | PDF | PubMed

89.

167
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Research article   Open Access

Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease

Margarita C Dinamarca, Juan P Sagal, Rodrigo A Quintanilla, Juan A Godoy, Macarena S Arrázola, Nibaldo C Inestrosa Molecular Neurodegeneration 2010, 5:4 (18 January 2010)

Abstract | Full text | PDF | PubMed

90.

167
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Research article   Open Access Highly Accessed

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun, Zezong Gu Molecular Neurodegeneration 2012, 7:21 (15 May 2012)

Abstract | Full text | PDF | PubMed

91.

166
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Research article   Open Access

ER stress response plays an important role in aggregation of α-synuclein

Peizhou Jiang, Ming Gan, Abdul Ebrahim, Wen-Lang Lin, Heather L Melrose, Shu-Hui C Yen Molecular Neurodegeneration 2010, 5:56 (13 December 2010)

Abstract | Full text | PDF | PubMed

92.

165
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Review   Open Access

What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

Dawn Teschendorf, Christopher D Link Molecular Neurodegeneration 2009, 4:38 (28 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

93.

165
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Research article   Open Access Highly Accessed

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

Masatoshi Konno, Takafumi Hasegawa, Toru Baba, Emiko Miura, Naoto Sugeno, Akio Kikuchi, Fabienne C Fiesel, Tsutomu Sasaki, Masashi Aoki, Yasuto Itoyama, Atsushi Takeda Molecular Neurodegeneration 2012, 7:38 (14 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

94.

164
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Research article   Open Access

DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease

Jianmin Chen, Mark L Cohen, Alan J Lerner, Yan Yang, Karl Herrup Molecular Neurodegeneration 2010, 5:60 (20 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

95.

164
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Research article   Open Access

Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

Rachel F Lane, Joshua W Gatson, Scott A Small, Michelle E Ehrlich, Sam Gandy Molecular Neurodegeneration 2010, 5:62 (30 December 2010)

Abstract | Full text | PDF | PubMed

96.

162
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Research article   Open Access Highly Accessed

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

Young-Don Kwak, Tao Ma, Shiyong Diao, Xue Zhang, Yaomin Chen, Janet Hsu, Stuart A Lipton, Eliezer Masliah, Huaxi Xu, Francesca-Fang Liao Molecular Neurodegeneration 2010, 5:49 (10 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

97.

163
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Research article   Open Access

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

Yoshihisa Kitamura, Shotaro Watanabe, Masanobu Taguchi, Kentaro Takagi, Takuya Kawata, Kazuko Takahashi-Niki, Hiroyuki Yasui, Hiroshi Maita, Sanae MM Iguchi-Ariga, Hiroyoshi Ariga Molecular Neurodegeneration 2011, 6:48 (8 July 2011)

Abstract | Full text | PDF | PubMed

98.

162
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Research article   Open Access

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

Jonathan H Fox, Teal Connor, Vanita Chopra, Kate Dorsey, Jibrin A Kama, Dorothee Bleckmann, Claudia Betschart, Daniel Hoyer, Stefan Frentzel, Marian DiFiglia, Paolo Paganetti, Steven M Hersch Molecular Neurodegeneration 2010, 5:26 (22 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

99.

161
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Review   Open Access Highly Accessed

Multiple pathways contribute to the pathogenesis of Huntington disease

Shihua Li, Xiao-Jiang Li Molecular Neurodegeneration 2006, 1:19 (16 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

100.

161
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Research article   Open Access

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

Elahe Taherzadeh-Fard, Carsten Saft, Denis A Akkad, Stefan Wieczorek, Aiden Haghikia, Andrew Chan, Jörg T Epplen, Larissa Arning Molecular Neurodegeneration 2011, 6:32 (19 May 2011)

Abstract | Full text | PDF | PubMed

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