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1.

857
Accesses

Methodology   Open Access

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman Molecular Neurodegeneration 2013, 8:13 (19 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

2.

787
Accesses

Review   Open Access Highly Accessed

α-Synuclein and neuronal cell death

Mark R Cookson Molecular Neurodegeneration 2009, 4:9 (4 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

758
Accesses

Review   Open Access Highly Accessed

The Alzheimer's disease β-secretase enzyme, BACE1

Sarah L Cole, Robert Vassar Molecular Neurodegeneration 2007, 2:22 (15 November 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

711
Accesses

Methodology   Open Access Highly Accessed

Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw Molecular Neurodegeneration 2013, 8:12 (8 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

667
Accesses

Review   Open Access Highly Accessed

Adult hippocampal neurogenesis and its role in Alzheimer's disease

Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)

Abstract | Full text | PDF | PubMed

6.

656
Accesses

Review   Open Access Highly Accessed

Regulated protein aggregation: stress granules and neurodegeneration

Benjamin Wolozin Molecular Neurodegeneration 2012, 7:56 (20 November 2012)

Abstract | Full text | PDF | PubMed

7.

623
Accesses

Review   Open Access Highly Accessed

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet Molecular Neurodegeneration 2013, 8:7 (29 January 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

606
Accesses

Review   Open Access Highly Accessed

The amyloid precursor protein: beyond amyloid

Hui Zheng, Edward H Koo Molecular Neurodegeneration 2006, 1:5 (3 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

562
Accesses

Review   Open Access Highly Accessed

Alzheimer's disease: synaptic dysfunction and Aβ

Ganesh M Shankar, Dominic M Walsh Molecular Neurodegeneration 2009, 4:48 (23 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

550
Accesses

Research article   Open Access

Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits

Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado Molecular Neurodegeneration 2013, 8:14 (26 April 2013)

Abstract | Full text | PDF | PubMed

11.

501
Accesses

Research article   Open Access

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013)

Abstract | Full text | PDF | PubMed

12.

441
Accesses

Review   Open Access Highly Accessed

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

Trent M Woodruff, John Thundyil, Sung-Chun Tang, Christopher G Sobey, Stephen M Taylor, Thiruma V Arumugam Molecular Neurodegeneration 2011, 6:11 (25 January 2011)

Abstract | Full text | PDF | PubMed

13.

430
Accesses

Research article   Open Access Highly Accessed

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

William A Eimer, Robert Vassar Molecular Neurodegeneration 2013, 8:2 (14 January 2013)

Abstract | Full text | PDF | PubMed

14.

423
Accesses

Research article   Open Access Highly Accessed

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg, Pamela J McLean Molecular Neurodegeneration 2012, 7:42 (24 August 2012)

Abstract | Full text | PDF | PubMed

15.

416
Accesses

Research article   Open Access Highly Accessed

Identification of BACE2 as an avid ß-amyloid-degrading protease

Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring Molecular Neurodegeneration 2012, 7:46 (17 September 2012)

Abstract | Full text | PDF | PubMed

16.

412
Accesses

Review   Open Access Highly Accessed

Does neuroinflammation fan the flame in neurodegenerative diseases?

Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine, Malú G Tansey Molecular Neurodegeneration 2009, 4:47 (16 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

409
Accesses

Review   Open Access Highly Accessed

Biology and pathophysiology of the amyloid precursor protein

Hui Zheng, Edward H Koo Molecular Neurodegeneration 2011, 6:27 (28 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

400
Accesses

Review   Open Access Highly Accessed

Tau exon 10 alternative splicing and tauopathies

Fei Liu, Cheng-Xin Gong Molecular Neurodegeneration 2008, 3:8 (10 July 2008)

Abstract | Full text | PDF | PubMed

19.

390
Accesses

Review   Open Access Highly Accessed

The role of tau in neurodegeneration

Tania F Gendron, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:13 (11 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

392
Accesses

Research article   Open Access

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease

Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Ceru', Sandra Moreno Molecular Neurodegeneration 2013, 8:8 (2 February 2013)

Abstract | Full text | PDF | PubMed

21.

388
Accesses

Review   Open Access Highly Accessed

Microglia in the aging brain: relevance to neurodegeneration

Xiao-Guang Luo, Jian-Qing Ding, Sheng-Di Chen Molecular Neurodegeneration 2010, 5:12 (24 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

349
Accesses

Review   Open Access Highly Accessed

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Philipp A Jaeger, Tony Wyss-Coray Molecular Neurodegeneration 2009, 4:16 (6 April 2009)

Abstract | Full text | PDF | PubMed

23.

345
Accesses

Research article   Open Access

Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression

Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett, Patricia A Trimmer Molecular Neurodegeneration 2013, 8:6 (26 January 2013)

Abstract | Full text | PDF | PubMed

24.

335
Accesses

Research article   Open Access

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

25.

324
Accesses

Research article   Open Access

Normal cognition in transgenic BRI2-Abeta mice

Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013)

Abstract | Provisional PDF | PubMed

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