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Research article   Open Access

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Bo Su, Haihua Liu, Xinglong Wang, Shu G Chen, Sandra L Siedlak, Eisaku Kondo, Raymond Choi, Atsushi Takeda, Rudy J Castellani, George Perry, Mark A Smith, Xiongwei Zhu, Hyoung-gon Lee Molecular Neurodegeneration 2009, 4:32 (23 July 2009)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis

Luis B Tovar-y-Romo, Luz Santa-Cruz, Ricardo Tapia Molecular Neurodegeneration 2009, 4:31 (20 July 2009)

Abstract | Full text | PDF | PubMed

Correction   Open Access

Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients

Zhenyu Zhong, Hikmet Nural, Ping He, Gina Civarella, Thomas Beach, Lucia Sue, Charles Adler, Holly Shill, John Caviness, Weiming Xia, Yong Shen Molecular Neurodegeneration 2009, 4:30 (15 July 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases

Keizo Sugaya, Shiro Matsubara Molecular Neurodegeneration 2009, 4:29 (15 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

Robert Tamayev, Dawang Zhou, Luciano D'Adamio Molecular Neurodegeneration 2009, 4:28 (14 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

Dale E Bredesen Molecular Neurodegeneration 2009, 4:27 (26 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy

Patricia A Trimmer, Kathleen M Schwartz, M Kathleen Borland, Luis De Taboada, Jackson Streeter, Uri Oron Molecular Neurodegeneration 2009, 4:26 (17 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

Javorina Milosevic, Sigrid C Schwarz, Vera Ogunlade, Anne K Meyer, Alexander Storch, Johannes Schwarz Molecular Neurodegeneration 2009, 4:25 (15 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

Kristen A Malkus, Elpida Tsika, Harry Ischiropoulos Molecular Neurodegeneration 2009, 4:24 (5 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients

Hikmet Nural, Ping He, Thomas Beach, Lucia Sue, Weiming Xia, Yong Shen Molecular Neurodegeneration 2009, 4:23 (4 June 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

An exo-cell assay for examining real-time γ-secretase activity and inhibition

Christopher C Shelton, Yuan Tian, Mark G Frattini, Yue-Ming Li Molecular Neurodegeneration 2009, 4:22 (2 June 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access

ApoE isoform-dependent changes in hippocampal synaptic function

Kimberly M Korwek, Justin H Trotter, Mary LaDu, Patrick M Sullivan, Edwin J Weeber Molecular Neurodegeneration 2009, 4:21 (27 May 2009)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Calcium signaling in neurodegeneration

Philippe Marambaud, Ute Dreses-Werringloer, Valérie Vingtdeux Molecular Neurodegeneration 2009, 4:20 (6 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

Monica Garcia-Alloza, Meenakshi Subramanian, Diana Thyssen, Laura A Borrelli, Abdul Fauq, Pritam Das, Todd E Golde, Bradley T Hyman, Brian J Bacskai Molecular Neurodegeneration 2009, 4:19 (6 May 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access

GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects

Kellen Voss, T Chris Gamblin Molecular Neurodegeneration 2009, 4:18 (2 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

Qiang Liu, Juan Zhang, Hien Tran, Marcel M Verbeek, Karina Reiss, Steven Estus, Guojun Bu Molecular Neurodegeneration 2009, 4:17 (16 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Philipp A Jaeger, Tony Wyss-Coray Molecular Neurodegeneration 2009, 4:16 (6 April 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Calnuc plays a role in dynamic distribution of Gαi but not Gβ subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells

Ping Lin, Thierry Fischer, Christine Lavoie, Haining Huang, Marilyn Farquhar Molecular Neurodegeneration 2009, 4:15 (25 March 2009)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Kiran Bhaskar, Megan Miller, Alexandra Chludzinski, Karl Herrup, Michael Zagorski, Bruce T Lamb Molecular Neurodegeneration 2009, 4:14 (16 March 2009)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

The role of tau in neurodegeneration

Tania F Gendron, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:13 (11 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains

Stéphanie Baulac, Hope Lu, Jennifer Strahle, Ting Yang, Matthew S Goldberg, Jie Shen, Michael G Schlossmacher, Cynthia A Lemere, Qun Lu, Weiming Xia Molecular Neurodegeneration 2009, 4:12 (25 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Andreas Weiss, Ana Roscic, Paolo Paganetti Molecular Neurodegeneration 2009, 4:11 (9 February 2009)

Abstract | Full text | PDF | PubMed

Short report   Open Access

PGC-1alpha as modifier of onset age in Huntington disease

Elahe Taherzadeh-Fard, Carsten Saft, Jürgen Andrich, Stefan Wieczorek, Larissa Arning Molecular Neurodegeneration 2009, 4:10 (6 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

α-Synuclein and neuronal cell death

Mark R Cookson Molecular Neurodegeneration 2009, 4:9 (4 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease

Todd E Golde Molecular Neurodegeneration 2009, 4:8 (4 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Commentary   Open Access

"What kills neurons in neurodegenerative diseases?", a review series in an open access journal

Todd E Golde, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:7 (4 February 2009)

Abstract | Full text | PDF | PubMed

Short report   Open Access

Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database

Kambiz N Alavian, Horst H Simon Molecular Neurodegeneration 2009, 4:6 (29 January 2009)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

Independent component analysis of Alzheimer's DNA microarray gene expression data

Wei Kong, Xiaoyang Mou, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Xudong Huang Molecular Neurodegeneration 2009, 4:5 (28 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Short report   Open Access

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

Ji Zhao, Lilin Li, Malcolm A Leissring Molecular Neurodegeneration 2009, 4:4 (14 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Short report   Open Access

The gene coding for PGC-1α modifies age at onset in Huntington's Disease

Patrick Weydt, Selma M Soyal, Cinzia Gellera, Stefano DiDonato, Claus Weidinger, Hannes Oberkofler, G Bernhard Landwehrmeyer, Wolfgang Patsch Molecular Neurodegeneration 2009, 4:3 (8 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

Alicia N Minniti, Daniela L Rebolledo, Paula M Grez, Ricardo Fadic, Rebeca Aldunate, Irene Volitakis, Robert A Cherny, Carlos Opazo, Colin Masters, Ashley I Bush, Nibaldo C Inestrosa Molecular Neurodegeneration 2009, 4:2 (6 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Jaya RP Prasanthi, Amber Huls, Sarah Thomasson, Alex Thompson, Eric Schommer, Othman Ghribi Molecular Neurodegeneration 2009, 4:1 (6 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation

Ayelén Bulloj, María C Leal, Ezequiel I Surace, Xue Zhang, Huaxi Xu, Maria D Ledesma, Eduardo M Castaño, Laura Morelli Molecular Neurodegeneration 2008, 3:22 (31 December 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

M Kathleen Borland, Patricia A Trimmer, Jeremy D Rubinstein, Paula M Keeney, KP Mohanakumar, Lei Liu, James P Bennett Molecular Neurodegeneration 2008, 3:21 (29 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

Chera L Maarouf, Ian D Daugs, Salvatore Spina, Ruben Vidal, Tyler A Kokjohn, R Lyle Patton, Walter M Kalback, Dean C Luehrs, Douglas G Walker, Eduardo M Castaño, Thomas G Beach, Bernardino Ghetti, Alex E Roher Molecular Neurodegeneration 2008, 3:20 (20 November 2008)

Abstract | Full text | PDF | PubMed

Methodology   Open Access Highly Accessed

In vivo silencing of alpha-synuclein using naked siRNA

Jada Lewis, Heather Melrose, David Bumcrot, Andrew Hope, Cynthia Zehr, Sarah Lincoln, Adam Braithwaite, Zhen He, Sina Ogholikhan, Kelly Hinkle, Caroline Kent, Ivanka Toudjarska, Klaus Charisse, Ravi Braich, Rajendra K Pandey, Michael Heckman, Demetrius M Maraganore, Julia Crook, Matthew J Farrer Molecular Neurodegeneration 2008, 3:19 (1 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression

Ya Wu, Ya Tang, Zhi Xiao, Zhen Bao, Bei He Molecular Neurodegeneration 2008, 3:18 (28 October 2008)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease

Caroline L Benn, Helen Fox, Gillian P Bates Molecular Neurodegeneration 2008, 3:17 (27 October 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

Thuzar M Shin, J Mario Isas, Chia-Ling Hsieh, Rakez Kayed, Charles G Glabe, Ralf Langen, Jeannie Chen Molecular Neurodegeneration 2008, 3:16 (21 October 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Evaluation of Dimebon in cellular model of Huntington's disease

Jun Wu, Qin Li, Ilya Bezprozvanny Molecular Neurodegeneration 2008, 3:15 (21 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

Károly Mirnics, Eric M Norstrom, Krassimira Garbett, Se Choi, Xiaoqiong Zhang, Philip Ebert, Sangram S Sisodia Molecular Neurodegeneration 2008, 3:14 (3 October 2008)

Abstract | Full text | PDF | PubMed

Short report   Open Access

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

Kathryn J Bryan, Xiongwei Zhu, Peggy L Harris, George Perry, Rudy J Castellani, Mark A Smith, Gemma Casadesus Molecular Neurodegeneration 2008, 3:13 (11 September 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

Luca Giliberto, Dawang Zhou, Richard Weldon, Elena Tamagno, Pasquale De Luca, Massimo Tabaton, Luciano D'Adamio Molecular Neurodegeneration 2008, 3:12 (2 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Prion protein lacks robust cytoprotective activity in cultured cells

Heather M Christensen, David A Harris Molecular Neurodegeneration 2008, 3:11 (21 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Short report   Open Access

MicroRNAs can regulate human APP levels

Neha Patel, David Hoang, Nathan Miller, Sara Ansaloni, Qihong Huang, Jack T Rogers, Jeremy C Lee, Aleister J Saunders Molecular Neurodegeneration 2008, 3:10 (6 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Nibaldo C Inestrosa, Enrique M Toledo Molecular Neurodegeneration 2008, 3:9 (24 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review   Open Access Highly Accessed

Tau exon 10 alternative splicing and tauopathies

Fei Liu, Cheng-Xin Gong Molecular Neurodegeneration 2008, 3:8 (10 July 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Autoimmune-induced preferential depletion of myelin-associated glycoprotein (MAG) is genetically regulated in relapsing EAE (B6 × SJL) F1 mice

Dusanka S Skundric, Rujuan Dai, Vaagn L Zakarian, Weili Zhou Molecular Neurodegeneration 2008, 3:7 (9 June 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

Donald B Carter, Edwige Dunn, Adele M Pauley, Denise D McKinley, Timothy J Fleck, Brenda R Ellerbrook, Nancy C Stratman, Xiangdong Zhou, Carol S Himes, Jeffrey S Nye, Alfredo Tomasselli, Riqiang Yan Molecular Neurodegeneration 2008, 3:6 (12 May 2008)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein

Celina V Zerbinatti, Joanna M Cordy, Ci-Di Chen, Maria Guillily, Sokreine Suon, William J Ray, Guy R Seabrook, Carmela R Abraham, Benjamin Wolozin Molecular Neurodegeneration 2008, 3:5 (18 March 2008)

Abstract | Full text | PDF | PubMed

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