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Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation
Kengo Uemura, Katherine C Farner, Navine Nasser-Ghodsi, Phill Jones, Oksana Berezovska Molecular Neurodegeneration 2011, 6:15 (10 February 2011)
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Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity
Pedro J Chacon, Rosa Garcia-Mejias, Alfredo Rodriguez-Tebar Molecular Neurodegeneration 2011, 6:14 (4 February 2011)
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Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway
Huang Guo, Theresa M Barrett, Zhihui Zhong, José A Fernández, John H Griffin, Robert S Freeman, Berislav V Zlokovic Molecular Neurodegeneration 2011, 6:13 (3 February 2011)
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Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
Timothy ME Scales, Pascal Derkinderen, Kit-Yi Leung, Helen L Byers, Malcolm A Ward, Caroline Price, Ian N Bird, Timothy Perera, Stuart Kellie, Ritchie Williamson, Brian H Anderton, C Hugh Reynolds Molecular Neurodegeneration 2011, 6:12 (26 January 2011)
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Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
Trent M Woodruff, John Thundyil, Sung-Chun Tang, Christopher G Sobey, Stephen M Taylor, Thiruma V Arumugam Molecular Neurodegeneration 2011, 6:11 (25 January 2011)
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Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation
Richard C Davis, Ian T Marsden, Michael T Maloney, Laurie S Minamide, Marcia Podlisny, Dennis J Selkoe, James R Bamburg Molecular Neurodegeneration 2011, 6:10 (24 January 2011)
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A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells
Joy X Lei, Cristina G Cassone, Christian Luebbert, Qing Liu Molecular Neurodegeneration 2011, 6:9 (21 January 2011)
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Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain
Frederick P Bellinger, Miyoko T Bellinger, Lucia A Seale, Andrea S Takemoto, Arjun V Raman, Takanori Miki, Amy B Manning-Boğ, Marla J Berry, Lon R White, G Ross Molecular Neurodegeneration 2011, 6:8 (21 January 2011)
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Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease
Jun Wang, Mario G Ferruzzi, Merina Varghese, Xianjuan Qian, Alice Cheng, Mathew Xie, Wei Zhao, Lap Ho, Giulio M Pasinetti Molecular Neurodegeneration 2011, 6:7 (19 January 2011)
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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
Elisa Greggio, Marco Bisaglia, Laura Civiero, Luigi Bubacco Molecular Neurodegeneration 2011, 6:6 (18 January 2011)
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MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease
Jean-Philippe Michaud, Karine L Richard, Serge Rivest Molecular Neurodegeneration 2011, 6:5 (14 January 2011)
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Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons
Wendi S Lambert, Lupe Ruiz, Samuel D Crish, Larry A Wheeler, David J Calkins Molecular Neurodegeneration 2011, 6:4 (13 January 2011)
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Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
Jon Salemi, Demian F Obregon, Anthony Cobb, Spenser Reed, Edin Sadic, Jingji Jin, Francisco Fernandez, Jun Tan, Brian Giunta Molecular Neurodegeneration 2011, 6:3 (11 January 2011)
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6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malley Molecular Neurodegeneration 2011, 6:2 (6 January 2011)
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Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
Hong Van B Che, Silke Metzger, Esteban Portal, Carolin Deyle, Olaf Riess, Huu Nguyen Molecular Neurodegeneration 2011, 6:1 (6 January 2011)
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Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1
Rachel F Lane, Joshua W Gatson, Scott A Small, Michelle E Ehrlich, Sam Gandy Molecular Neurodegeneration 2010, 5:62 (30 December 2010)
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Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
Manuel T Gersbacher, Doo Kim, Raja Bhattacharyya, Dora M Kovacs Molecular Neurodegeneration 2010, 5:61 (23 December 2010)
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DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease
Jianmin Chen, Mark L Cohen, Alan J Lerner, Yan Yang, Karl Herrup Molecular Neurodegeneration 2010, 5:60 (20 December 2010)
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Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
Roongpetch Keowkase, Marwa Aboukhatwa, Bao-Ling Adam, J Warren Beach, Alvin V Terry, Jerry J Buccafussco, Yuan Luo Molecular Neurodegeneration 2010, 5:59 (16 December 2010)
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Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
Kimberly B Kegel, Ellen Sapp, Jonathan Alexander, Patrick Reeves, Dorothee Bleckmann, Linsday Sobin, Nicholas Masso, Antonio Valencia, Hyunkyung Jeong, Dimitri Krainc, James Palacino, Daniel Curtis, Rainer Kuhn, Claudia Betschart, Miguel Sena-Esteves, Neil Aronin, Paolo Paganetti, Marian DiFiglia Molecular Neurodegeneration 2010, 5:58 (14 December 2010)
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Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
Rakez Kayed, Isabel Canto, Leonid Breydo, Suhail Rasool, Tamas Lukacsovich, Jessica Wu, Ricardo Albay, Anna Pensalfini, Stephen Yeung, Elizabeth Head, J Lawrence Marsh, Charles Glabe Molecular Neurodegeneration 2010, 5:57 (13 December 2010)
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ER stress response plays an important role in aggregation of α-synuclein
Peizhou Jiang, Ming Gan, Abdul Ebrahim, Wen-Lang Lin, Heather L Melrose, Shu-Hui C Yen Molecular Neurodegeneration 2010, 5:56 (13 December 2010)
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α-synuclein induced synapse damage is enhanced by amyloid-β1-42
Clive Bate, Steve Gentleman, Alun Williams Molecular Neurodegeneration 2010, 5:55 (7 December 2010)
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ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics
Shuchen Lee, Guang Yang, Yue Yong, Ying Liu, Liyun Zhao, Jing Xu, Xiaomin Zhang, Yanjie Wan, Chun Feng, Zhiqin Fan, Yong Liu, Jia Luo, Zun-Ji Ke Molecular Neurodegeneration 2010, 5:54 (27 November 2010)
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Age-related synaptic loss of the medial olivocochlear efferent innervation
Benjamin Fu, Colleen Le Prell, Dwayne Simmons, Debin Lei, Angela Schrader, Amelia B Chen, Jianxin Bao Molecular Neurodegeneration 2010, 5:53 (26 November 2010)
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A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport
Lina Wang, Anthony Brown Molecular Neurodegeneration 2010, 5:52 (18 November 2010)
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Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation
Antonella Caccamo, Andrea Magrí, Salvatore Oddo Molecular Neurodegeneration 2010, 5:51 (11 November 2010)
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Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy
Ana G Barbeito, Thierry Levade, Marie B Delisle, Bernardino Ghetti, Ruben Vidal Molecular Neurodegeneration 2010, 5:50 (10 November 2010)
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NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
Young-Don Kwak, Tao Ma, Shiyong Diao, Xue Zhang, Yaomin Chen, Janet Hsu, Stuart A Lipton, Eliezer Masliah, Huaxi Xu, Francesca-Fang Liao Molecular Neurodegeneration 2010, 5:49 (10 November 2010)
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Aminopeptidases do not directly degrade tau protein
K Chow, Hanjun Guan, Louis B Hersh Molecular Neurodegeneration 2010, 5:48 (5 November 2010)
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Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model
Preeti J Khandelwal, Sonya B Dumanis, Li Feng, Kathleen Maguire-Zeiss, GW Rebeck, Hilal A Lashuel, Charbel EH Moussa Molecular Neurodegeneration 2010, 5:47 (4 November 2010)
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Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
Xu Wang, Wei Zheng, Jing-Wei Xie, Tao Wang, Si-Ling Wang, Wei-Ping Teng, Zhan-You Wang Molecular Neurodegeneration 2010, 5:46 (2 November 2010)
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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
John C O'Leary, Qingyou Li, Paul Marinec, Laura J Blair, Erin E Congdon, Amelia G Johnson, Umesh K Jinwal, John Koren, Jeffrey R Jones, Clara Kraft, Melinda Peters, Jose F Abisambra, Karen E Duff, Edwin J Weeber, Jason E Gestwicki, Chad A Dickey Molecular Neurodegeneration 2010, 5:45 (1 November 2010)
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Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats
Sokreine Suon, Jie Zhao, Stephanie A Villarreal, Nikesh Anumula, Mali Liu, Linda M Carangia, John J Renger, Celina V Zerbinatti Molecular Neurodegeneration 2010, 5:44 (29 October 2010)
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Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease
James B Koprich, Tom H Johnston, M Gabriela Reyes, Xuan Sun, Jonathan M Brotchie Molecular Neurodegeneration 2010, 5:43 (28 October 2010)
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Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
Shuwen Cao, Shaji Theodore, David G Standaert Molecular Neurodegeneration 2010, 5:42 (26 October 2010)
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Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1
Babykumari P Chitramuthu, David C Baranowski, Denis G Kay, Andrew Bateman, Hugh PJ Bennett Molecular Neurodegeneration 2010, 5:41 (14 October 2010)
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Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
Sandra I Vieira, Sandra Rebelo, Hermann Esselmann, Jens Wiltfang, James Lah, Rachel Lane, Scott A Small, Sam Gandy, Edgar F da Cruz e Silva, Odete AB da Cruz e Silva Molecular Neurodegeneration 2010, 5:40 (11 October 2010)
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The biochemical aftermath of anti-amyloid immunotherapy
Chera L Maarouf, Ian D Daugs, Tyler A Kokjohn, Walter M Kalback, R Lyle Patton, Dean C Luehrs, Eliezer Masliah, James AR Nicoll, Marwan N Sabbagh, Thomas G Beach, Eduardo M Castaño, Alex E Roher Molecular Neurodegeneration 2010, 5:39 (7 October 2010)
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Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease
Rita De Gasperi, Miguel Sosa, Stella Dracheva, Gregory A Elder Molecular Neurodegeneration 2010, 5:38 (23 September 2010)
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BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
Annica Sjölander, Henrik Zetterberg, Ulf Andreasson, Lennart Minthon, Kaj Blennow Molecular Neurodegeneration 2010, 5:37 (17 September 2010)
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Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?
Afia Akram, James Schmeidler, Pavel Katsel, Patrick R Hof, Vahram Haroutunian Molecular Neurodegeneration 2010, 5:36 (15 September 2010)
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Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
Maho Kondo, Maki Shiono, Genzo Itoh, Norio Takei, Takahide Matsushima, Masahiro Maeda, Hidenori Taru, Saori Hata, Tohru Yamamoto, Yuhki Saito, Toshiharu Suzuki Molecular Neurodegeneration 2010, 5:35 (15 September 2010)
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Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism
Laura S Dieter, Steven Estus Molecular Neurodegeneration 2010, 5:34 (7 September 2010)
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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
Yong-Jie Zhang, Tania F Gendron, Ya-Fei Xu, Li-Wen Ko, Shu-Hui Yen, Leonard Petrucelli Molecular Neurodegeneration 2010, 5:33 (30 August 2010)
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Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
Ethan A Winkler, Robert D Bell, Berislav V Zlokovic Molecular Neurodegeneration 2010, 5:32 (25 August 2010)
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BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
Brian D Hitt, Thomas C Jaramillo, Dane M Chetkovich, Robert Vassar Molecular Neurodegeneration 2010, 5:31 (23 August 2010)
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Prolonged Aβ treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis
Lana Shabala, Claire Howells, Adrian K West, Roger S Chung Molecular Neurodegeneration 2010, 5:30 (13 August 2010)
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Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells
Alessandro Didonna, Giuseppe Legname Molecular Neurodegeneration 2010, 5:29 (9 August 2010)
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No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice
Haiyan Shen, Jonathan I Matsui, Debin Lei, Lirong Han, Kevin K Ohlemiller, Jianxin Bao Molecular Neurodegeneration 2010, 5:28 (16 July 2010)
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