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Does a loss of TDP-43 function cause neurodegeneration?
Zuo-Shang Xu Molecular Neurodegeneration 2012, 7:27 (14 June 2012)
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A molecular signature in blood identifies early Parkinson’s disease
Leonid Molochnikov, Jose M Rabey, Evgenya Dobronevsky, Ubaldo Bonuccelli, Roberto Ceravolo, Daniela Frosini, Edna Grünblatt, Peter Riederer, Christian Jacob, Judith Aharon-Peretz, Yulia Bashenko, Moussa BH Youdim, Silvia A Mandel Molecular Neurodegeneration 2012, 7:26 (31 May 2012)
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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany Dugger, Beate Winner, Iryna Prots, Caroline B Kent, Kenya Nishioka, Wen-Lang Lin, Dennis W Dickson, Christopher J Janus, Matthew J Farrer, Heather L Melrose Molecular Neurodegeneration 2012, 7:25 (30 May 2012)
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Editor’s summary
LRRK2 knockout mice have a normal dopaminergic system and do not develop any pathological features of Parkinsons disease, but they do display altered exploratory and motor co-ordination behaviors, and degeneration in the kidney.
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Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
Zhao-Hui Xu, Qi Yang, Bin Feng, Shui-bing Liu, Nan Zhang, Jiang-hao Xing, Xiao-Qiang Li, Yu-mei Wu, Guo-Dong Gao, Ming-Gao Zhao Molecular Neurodegeneration 2012, 7:24 (28 May 2012)
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Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
Nicole L Bjorklund, Lindsay C Reese, V-M Sadagoparamanujam, Valeria Ghirardi, Randall L Woltjer, Giulio Taglialatela Molecular Neurodegeneration 2012, 7:23 (28 May 2012)
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Regulation of mitochondrial permeability transition pore by PINK1
Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Núñez, Zhiyin Song, David Chan, Carlos Villalobos, Jie Shen Molecular Neurodegeneration 2012, 7:22 (25 May 2012)
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Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia
Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun, Zezong Gu Molecular Neurodegeneration 2012, 7:21 (15 May 2012)
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Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease
Keizo Sugaya, Shiro Matsubara Molecular Neurodegeneration 2012, 7:20 (14 May 2012)
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Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
Robert Tamayev, Luciano D’Adamio Molecular Neurodegeneration 2012, 7:19 (26 April 2012)
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Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity
Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins Molecular Neurodegeneration 2012, 7:18 (26 April 2012)
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Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia
Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren, Changlian Zhu Molecular Neurodegeneration 2012, 7:17 (25 April 2012)
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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects
Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki, the Japanese Alzheimer's Disease Neuroimaging Initiative Molecular Neurodegeneration 2012, 7:16 (25 April 2012)
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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima, Sadahiro Azuma, Etsuro Ohta, Fumiya Obata Molecular Neurodegeneration 2012, 7:15 (25 April 2012)
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Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling
Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman, David M Holtzman Molecular Neurodegeneration 2012, 7:14 (18 April 2012)
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Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
Mariet Allen, Fanggeng Zou, High Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak, Sumit Middha, Sooraj Maharjan, Constantin Georgescu, Debra Schultz, Fariborz Rakhshan, Christopher P Kolbert, Jin Jen, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner et al.
Molecular Neurodegeneration 2012, 7:13 (11 April 2012)
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Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine, Marie-Françoise Chesselet Molecular Neurodegeneration 2012, 7:12 (4 April 2012)
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Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo, Francisca C Bronfman Molecular Neurodegeneration 2012, 7:11 (29 March 2012)
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Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia Molecular Neurodegeneration 2012, 7:10 (24 March 2012)
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FE65 as a link between VLDLR and APP to regulate their trafficking and processing
Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guénette, Toshiharu Suzuki, Paul M Mathews, Daniel TS Pak, G William Rebeck, Yoo-hun Suh, Hee-Sae Park, Hyang-Sook Hoe Molecular Neurodegeneration 2012, 7:9 (19 March 2012)
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Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley, Mary Jo LaDu Molecular Neurodegeneration 2012, 7:8 (16 March 2012)
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Rapid glutamate receptor 2 trafficking during retinal degeneration
Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc Molecular Neurodegeneration 2012, 7:7 (10 February 2012)
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Spinal cord trauma and the molecular point of no return
Ping K Yip, Andrea Malaspina Molecular Neurodegeneration 2012, 7:6 (8 February 2012)
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WldS
but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
Jo Ann V Antenor-Dorsey, Karen L O'Malley Molecular Neurodegeneration 2012, 7:5 (8 February 2012)
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Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
Xin Heng, Gang Jin, Xin Zhang, Dehuang Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le Molecular Neurodegeneration 2012, 7:4 (2 February 2012)
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Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven Molecular Neurodegeneration 2012, 7:3 (16 January 2012)
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