This article is part of the supplement: Proceedings of the 2011 International Conference on Molecular Neurodegeneration
Meeting abstract
Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats
1 Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
2 Department of Pharmacology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
Molecular Neurodegeneration 2012, 7(Suppl 1):S20 doi:10.1186/1750-1326-7-S1-S20
Published: 7 February 2012First paragraph (this article has no abstract)
Oxidative DNA damage generated by 6-hydroxydopamine (6-OHDA) may initiate a programmed cell death cascade called apoptosis and plays an important role in the pathogenesis of Parkinson’s disease (PD). ProNGF, a precursor of nerve growth factor (NGF), is found to be involved in neuronal apoptosis of neurodegenerative diseases such as PD. Therefore, we have tested the presumption that proNGF-mediated apoptosis might be initiated by oxidative DNA damage in 6-OHDA treated rats.