Email updates

Keep up to date with the latest news and content from Molecular Neurodegeneration and BioMed Central.

Open Access Research article

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

Robert Tamayev1, Nsikan Akpan2, Ottavio Arancio24, Carol M Troy234 and Luciano D’Adamio1*

Author Affiliations

1 Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

2 Departments of Pathology & Cell Biology, Columbia University, New York, NY, 10032, USA

3 Departments of Neurology, Columbia University, New York, NY, 10032, USA

4 Departments of Taub Institute for the Study of Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA

For all author emails, please log on.

Molecular Neurodegeneration 2012, 7:60  doi:10.1186/1750-1326-7-60

Published: 10 December 2012

Abstract

Background

Mutations in either Aβ Precursor protein (APP) or genes that regulate APP processing, such as BRI2/ITM2B and PSEN1/PSEN2, cause familial dementias. Although dementias due to APP/PSEN1/PSEN2 mutations are classified as familial Alzheimer disease (FAD) and those due to mutations in BRI2/ITM2B as British and Danish dementias (FBD, FDD), data suggest that these diseases have a common pathogenesis involving toxic APP metabolites. It was previously shown that FAD mutations in APP and PSENs promote activation of caspases leading to the hypothesis that aberrant caspase activation could participate in AD pathogenesis.

Results

Here, we tested whether a similar mechanism applies to the Danish BRI2/ITM2B mutation. We have generated a genetically congruous mouse model of FDD, called FDDKI, which presents memory and synaptic plasticity deficits. We found that caspase-9 is activated in hippocampal synaptic fractions of FDDKI mice and inhibition of caspase-9 activity rescues both synaptic plasticity and memory deficits.

Conclusion

These data directly implicate caspase-9 in the pathogenesis of Danish dementia and suggest that reducing caspase-9 activity is a valid therapeutic approach to treating human dementias.