Axonal transport partially recovers after exposure to hydrogen peroxide. Transport was imaged in cultures that were exposed to 100 μM hydrogen peroxide for 1 h, that were exposed for 1 h then allowed to recover for 1 h, or that were mock-treated. A. After recovery, mitochondrial transport remained significantly reduced compared to control cells (*** P < 0.001, student t-test). In the case of Golgi-derived vesicles, both the number of transport events (B) and the velocity of transport (C) fully recovered after hydrogen peroxide treatment (P > 0.5, student t-test). Error bar indicates SD.
Fang et al. Molecular Neurodegeneration 2012 7:29 doi:10.1186/1750-1326-7-29