Hydrogen peroxide inhibits mitochondrial axonal transport.A. Representative kymographs of mitochondrial transport at varying times after exposure to 100 μM hydrogen peroxide. B. Quantitative analysis of mitochondrial transport following hydrogen peroxide treatment (n = 20 cells). The number of anterograde and retrograde events (normalized to each cell’s pretreatment levels) decreased over time (control, open circle; hydrogen peroxide treatment, filled circle). The transport at each time point was compared with pre-treatment levels using paired student t-test (* P < 0.05; ** P < 0.01; *** P < 0.001). Error bar indicates SD.
Fang et al. Molecular Neurodegeneration 2012 7:29 doi:10.1186/1750-1326-7-29