Open Access Highly Accessed Research article

Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

Mariet Allen1, Fanggeng Zou1, High S Chai2, Curtis S Younkin1, Richard Miles1, Asha A Nair2, Julia E Crook3, V S Pankratz2, Minerva M Carrasquillo1, Christopher N Rowley1, Thuy Nguyen1, Li Ma1, Kimberly G Malphrus1, Gina Bisceglio1, Alexandra I Ortolaza1, Ryan Palusak1, Sumit Middha2, Sooraj Maharjan2, Constantin Georgescu1, Debra Schultz4, Fariborz Rakhshan4, Christopher P Kolbert4, Jin Jen4, Sigrid B Sando5,6, Jan O Aasly5,6, Maria Barcikowska7, Ryan J Uitti8, Zbigniew K Wszolek8, Owen A Ross1, Ronald C Petersen9, Neill R Graff-Radford8, Dennis W Dickson1, Steven G Younkin1 and Nilüfer Ertekin-Taner1,8*

1 Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA

2 Mayo Clinic Minnesota, Department of Biostatistics, Rochester, MN, USA

3 Mayo Clinic Florida, Biostatistics Unit, Jacksonville, FL, USA

4 Mayo Clinic Minnesota, Gene Expression Core, Advanced Genome Technology Center, Rochester, MN, USA

5 Department of Neurology, St.Olav's Hospital, Edvard Griegs Gate 8, 7006 Trondheim, Norway

6 Department of Neuroscience, Norwegian University of Science and Technology, NTNU, 7491 Trondheim, Norway

7 Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

8 Mayo Clinic Florida, Department of Neurology, Jacksonville, FL, USA

9 Mayo Clinic Minnesota, Department of Neurology, Rochester, MN, USA

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Molecular Neurodegeneration 2012, 7:13 doi:10.1186/1750-1326-7-13

Published: 11 April 2012

Additional files

Additional file 1:

"123011_GSTO_ms_SupplementaryText.docx", supplementary tables (SupplTable 1, 2), text and figure legends (SupplFigure 1, 2a, b), relevant to the manuscript.

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Additional file 2:

"Suppl_Figure 1_ExpressionPlot_120511_MA.tif" Supplementary Figure 1.

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Additional file 3:

"Suppl_Figure 2a_Glutathione metabolism_Humanversion_12-02-2011.tif" Supplementary Figure 2a.

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Additional File 4:

"Suppl_Figure 2b_MetaCoreLegend_pic.tif" Supplementary Figure 2b.

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