Research article
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
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* Corresponding author: Gopal Thinakaran gopal@uchicago.edu
1 Departments of Neurobiology, Neurology, and Pathology, The University of Chicago, Chicago, IL, 60637, USA
2 Committee on Neurobiology, The University of Chicago, Chicago, IL, 60637, USA
3 Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, IL, 60637, USA
4 Department of Surgery, The University of Chicago, Chicago, IL, 60637, USA
5 Departments of Medicine and Psychiatry, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, T6G 2R7, Canada
Molecular Neurodegeneration 2011, 6:87 doi:10.1186/1750-1326-6-87
Published: 28 December 2011Additional files
Neurological defects in Hup23 mice from 6 transgenic lines. Hup23 mice from 6 transgenic lines display similar neurological defects with different levels of severity depending on the level of transgene expression. The videos were recorded on the days indicated in each panel.
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Side view of Hup23 line 43 mouse on a stationary DigiGait treadmill. A closer view of Hup23 mouse from line 43 displaying the complex neurological defects (right) and its Ntg littermate (left). The videos were recorded on P30 when the animals were placed on a stationary DigiGait treadmill.
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Side view of Hup23 line 43 mouse running on DigiGait treadmill. Side view of Hup23 mouse from line 43 and Ntg littermate running on the DigiGait treadmill held at the speed of 20 cm/sec. The videos were recorded on P30.
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Bottom view of Hup23 line 74 mouse running on DigiGait treadmill. Bottom view of a Hup23 mouse from line 74 and Ntg littermate running on the DigiGait treadmill held at the speed of 20 cm/sec. The videos were recorded on P30.
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Rapid decline of Hup23 line 74 mouse performance on DigiGait treadmill. The same Hup23 mouse from line 74 shows declined performance on the treadmill over a period of 6 days. The videos were recorded on P30 (top), P35 (middle), and P41 (bottom). Note that the treadmill is held at different speeds.
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Additional file 6:
Analysis of p23 and synaptic marker expression. Double immunofluorescence analysis of calbindin and VGLUT1 or VGLUT-2 labeling in cerebellum of non-transgenic animals. The following areas are indicated: Pcl, Purkinje cell layer; gcl, granule cell layer, ml, molecular layer.
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