Table 1 |
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|
Summary of neurogenesis changes in transgenic mouse models of AD |
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|
Genetic Manipulation |
Strain Name |
Genotype |
Promoter |
Age (mon) |
Pathology (Aβ deposition) |
Neurogenesis assessment |
Effect |
Reference |
|
|
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|
Knock-in |
mo PS1M146V/- |
3 |
BrdU injection twice daily (2 hr apart) for 4 consecutive days |
Decreased proliferation and differentiation |
[36] |
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|
hu ApoE4 |
3, 6-7, 12-13 |
BrdU injection twice (6 hr apart) |
Diminished neuronal maturation |
[41] |
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|
mo APPswe/PS1ΔE9 |
8-9 18-24 |
post |
DCX, MCM2 immunostaining |
Decreased proliferation |
[42] |
|||
|
Transgenic |
hu PS1P117L |
NSE |
3-4 |
one BrdU injection per day for 12 consecutive days |
Decreased survival |
[37] |
||
|
hu PS1ΔE9, hu PS1M146L |
PrP |
3 |
single injection of BrdU |
Decreased proliferation and differentiation |
[38] |
|||
|
Tg2576 |
chimeric mo-hu APPswe |
PrP |
12-14 |
pre |
five daily injections of BrdU |
Decreased proliferation, survival and differentiation |
[39] |
|
|
PDAPP |
hu APPind |
PDGF |
2 12 |
pre post |
one i.p. injection of BrdU |
Decreased proliferation and survival |
[40] |
|
|
APP/PS1 |
chimeric mo-hu APPswe/hu PS1ΔE9 |
PrP |
6 |
pre, post |
BrdU injection once daily for 12 consecutive days |
Decreased survival |
[43] |
|
|
APP/PS1 |
chimeric mo-hu APPswe/hu PS1ΔE9 |
PrP |
2 |
pre |
BrdU injection every 12 hr for 3 days |
Decreased proliferation and differentiation |
[44] |
|
|
3xTg-AD |
hu APPswe/PS1M146V/tauP301L |
Thy-1.2 |
4, 9 |
Decreased proliferation |
[45] |
|||
|
J20 |
hu APPswe, ind |
PDGF |
3, 12 |
pre, post |
BrdU injection twice daily (8 hr apart) for 3 consecutive days |
Increased proliferation and differentiation |
[46] |
|
|
J20 |
hu APPswe, ind |
PDGF |
3, 5, 9, 11 |
pre, post |
daily injection of BrdU for 5 days |
Increased proliferation and differentiation |
[47] |
|
|
J20 |
hu APPswe, ind |
PDGF |
2-3 |
pre |
BrdU injection for 3 days |
Accelarated early development but impaired late maturation of newborn neurons |
[48] |
|
|
Knock-out |
ApoE |
3, 6-7, 12-13 |
BrdU injection twice (6 hr apart) |
Reduced neurogenesis but increased astrogenesis |
[41] |
|||
|
PS1/PS2 forebrain KO |
7-9 18-20 |
single dose injection of BrdU |
Enhanced cell proliferation at early stages of neurodegeneration but impaired survival at late stages |
[49] |
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|
|
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|
Mu and Gage Molecular Neurodegeneration 2011 6:85 doi:10.1186/1750-1326-6-85 |
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