Table 3 |
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|
α-synuclein-regulated genes associated with neurological or vascular diseases |
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|
Hs orthologs Affymetrix (HGU-133A) |
Gene symbol: short description |
ASO mice |
Neurological disease |
|
|
|
||||
|
fold change |
p- value |
|||
|
|
||||
|
200862_AT |
Dhcr24: 24-dehydrocholesterol reductase |
6.1 |
2E-05 |
AD |
|
206590_X_AT |
Drd2: dopamine receptor D2 |
3.3 |
8E-05 |
Al, BD, Diab. |
|
206713_AT |
Ntng1: netrin G1 |
2.5 |
2E-04 |
Sch. |
|
212762_S_AT |
Tf7l2: transcription factor 7-like 2 |
2.1 |
2E-04 |
Diab. |
|
205013_S_AT |
Adora2a: adenosine A2a receptor |
2.0 |
2E-05 |
Anx, ADHD, |
|
201847_AT |
Lip1: lipase 1, cholesterol esterase |
1.9 |
2E-03 |
AD |
|
218489_S_AT |
Alad: aminolevulinate, δ-dehydratase |
1.5 |
2E-04 |
ALS, Al, Pb Tx |
|
203146_S_AT |
Gabbr1: γ-aminobutyric acid receptor 1 |
1.5 |
4E-04 |
ADHD, Ep, Sc. |
|
211026_S_AT |
Mgll: monoglyceride lipase |
1.5 |
2E-05 |
Al. |
|
209702_AT |
Fto: fat mass and obesity associated |
1.5 |
1E-03 |
Diab. |
|
212560_AT |
Sorl1: sortilin-related receptor, LDLR class A |
-1.5 |
3E-05 |
AD |
|
210381_S_AT |
Cckbr: cholecystokinin B receptor |
-1.5 |
3E-03 |
PD, Sc, Diab. |
|
205525_AT |
Cald1: caldesmon 1 |
-1.5 |
1E-03 |
Diab. |
|
212382_AT |
Tcf4: transcription factor 4 |
-1.5 |
3E-03 |
Sc. |
|
209189_AT |
Fos: FBJ osteosarcoma oncogene |
-1.6 |
6E-04 |
AD |
|
203293_S_AT |
Lman1: lectin, mannose-binding, 1 |
-1.6 |
2E-03 |
At, CAD, Inf. D |
|
209101_AT |
Ctgf: connective tissue growth factor |
-1.6 |
7E-05 |
Diab. |
|
216248_S_AT |
Nr4a2: nuclear receptor subfamily. 4, group A, member 2 |
-1.7 |
5E-05 |
PD, ADHD, BD, |
|
201348_AT |
Gpx3: glutathione peroxidase 3 (plasma) |
-1.9 |
2E-04 |
Diab. |
|
204729_S_AT |
Stx1a: syntaxin 1A (brain) |
-1.9 |
2E-05 |
Diab. |
|
202291_S_AT |
Mglap: matrix Gla protein |
-2.0 |
2E-05 |
At, Pb Tx |
|
206577_AT |
Vip: vasoactive intestinal peptide |
-2.0 |
2E-05 |
MS |
|
207848_AT |
Avp: arginine vasopressin |
-2.0 |
2E-05 |
Diab., Dement. |
|
205352_AT |
Serpina3n/serpin p. inhibitor, cl. A member 3n |
-2.8 |
3E-05 |
Dement. |
|
206622_AT |
Thr: thyrotropin-releasing hormone |
-8.0 |
1E-03 |
Hypertension |
|
215775_AT |
Thbs1: thrombospondin 1 |
-13.0 |
7E-04 |
At, CAD |
|
212412_AT |
Pdzl: PDZ and LIM domain 5 |
-16.0 |
3E-04 |
BD, Sc. |
|
|
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|
Abbreviations: D: Disease/Disorder; ADHD: Attention deficit hyperactivity D; AD: Alzheimer's D; Al: Alcoholism; ALS: Amyotrophic lateral sclerosis; Anx: Anxiety D; At: Atherosclerosis; BD: Bipolar D.; CAD: Coronary artery D; Dement: Dementia; Diab: Diabetes; Ep: Epilepsy; Hs: Homo sapiens; Inf. D: Inflammatory D; MS: Multiple sclerosis; Pb Tx: Lead toxicity; PD: Parkinson's D.; Sc: Schizophrenia |
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|
Cabeza-Arvelaiz et al. Molecular Neurodegeneration 2011 6:83 doi:10.1186/1750-1326-6-83 |
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