Table 1

Regional distribution of pathologies in TDP-43_M337V mice

Cortex, layer V

Hippocampus

Striatum

Brainstem

Cerebellum

Anterior horn of spinal cord

Posterior horn of spinal cord

Cytoplasmic TDP-43

+

-

-

+

-

++

+

Nuclear pTDP-43

-

-

-

+/-

-

++

+

Cytoplasmic pTDP-43

++

-

-

+

-

++

+

Ubiquitination

++

+

+

++

-

++

++

IBA-1-positive microglia

+

-

-

++

-

++

+

GFAP-positive astrocytes

+

-

-

++

-

++

+

Mitochondrial aggregates

+

-

-

+

-

++

+

p-tau

++

++

+

+

-

+/-

+/-

Xu et al. Molecular Neurodegeneration 2011 6:73   doi:10.1186/1750-1326-6-73