Reduced expression of the adaptor protein MyD88 in APPswe/PS1 mice accelerates spatial memory deficits in the T-water maze paradigm. Mice were trained to reach the hidden platform on one arm of the T-water maze apparatus. (a) Number of trials and time spent (c) to learn the task were measured. All different strains of each ages performed similarly. Spatial learning and memory of trained mice was challenged 48 hours later (Reversal phase). Compared with APPswe/PS1 mice and their controls, APPswe/PS1-MyD88+/- transgenic mice showed a greater decline of spatial cognitive capacities measured by the number of errors (b) and time spent (d) to reach the platform. Error bars represent SEM; n = 8-11; * P < 0.05 (vs WT and MyD88-/-), ** P < 0.01 (vs WT and MyD88-/-), *** P < 0.001 (vs WT and MyD88-/-), # P < 0.05 (vs APPswe/PS1), ## P < 0.01 (vs APPswe/PS1), ### P < 0.001 (vs APPswe/PS1). (Statistical analysis was performed using one-way ANOVA followed by a Bonferroni or Tamhane's post-hoc test).
Michaud et al. Molecular Neurodegeneration 2011 6:5 doi:10.1186/1750-1326-6-5