Figure 9.

Combined GSI + Qa treatment prevented dendritic degeneration more effectively than GSI or Qa alone. A-C. Golgi silver staining in dendrites in layer 6 of the cortex (A), hippocampal CA1 region (B), and the medial nuclei of the thalamus (C). D-F. Bar graphs of the dendrites load in the three regions respectively as determined by morphometry. RML infected untreated mice (UnTx) shows severe dendritic atrophy. Prevention of dendritic loss was associated with GSI + Qa treatment. Measurements of dendrite loads in each of the three brain regions are shown as a function of the treatment. Student t test probabilities (n = 3 mice each): * P ≤ 0.05; **P ≤ 0.01. Scale bars represent 30 μm and apply to each image in the same row. Adapted from Spilman et al. [8].