Figure 1.

Subcellular kinetics of log total PrP27-30 (μg) in the thalamus (A) and neocortex (B) throughout the course of Sc237 scrapie in Syrian hamster. Hamsters were inoculated intrathalamically. PrP27-30 was measured by conformation-dependent immunoassay. Percoll gradient fractions: "plasma" membrane fraction; endosomal fraction; lysosomal fraction.