Research article
Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease
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* Corresponding author: Nibaldo C Inestrosa ninestrosa@bio.puc.cl
- † Equal contributors
Centro de Regulación Celular y Patología "Joaquín V. Luco" (CRCP), Instituto Milenio MIFAB, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, 8331010 Santiago, Chile
Molecular Neurodegeneration 2010, 5:4 doi:10.1186/1750-1326-5-4
Published: 18 January 2010Additional files
Additional file 1:
Characterization of the aggregates used for the experiments by electron microscopy. Negative stain and electron microscopy photographs for 5 μM of (A) Aβ-AChEf and (B) Aβ-AChEo preparations used in the experiments.
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Additional file 2:
Effect of Aβ and Aβ-AChE aggregates on synaptic proteins. Immunofluorescence assay for PSD-95 of hippocampal neurons treated with (A) control or 1 μM of (B) Aβo, (C) Aβf, (D) Aβ-AChEo, (E) Aβ-AChEf. Also a magnification of neurites in each treatment is showing. The imunofluorescence correspond to synapsin-1 (red) and PSD-95 (green).
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