Molecular Neurodegeneration

official impact factor 5.36

Open Access Research article

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

Brian D Hitt1, Thomas C Jaramillo2, Dane M Chetkovich2,3 and Robert Vassar1*

Author Affiliations

1 Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

2 Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

3 Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

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Molecular Neurodegeneration 2010, 5:31 doi:10.1186/1750-1326-5-31

Published: 23 August 2010

Additional files

Additional file 1:

Video 1. Video monitoring and corresponding EEG trace of BACE1-/- mouse exhibiting typical generalized tonic-clonic seizure.

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Additional file 2:

Video 2. Video monitoring of the onset of 3 distinct generalized tonic-clonic seizures in BACE1-/- mice, demonstrating atonia at seizure onset.

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