Research article
Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
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* Corresponding author: James P Bennett jpbennett@vcu.edu
Morris K Udall Parkinson's Disease Research Center of Excellence, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Molecular Neurodegeneration 2009, 4:37 doi:10.1186/1750-1326-4-37
Published: 23 September 2009Additional files
Additional file 1:
Clinical characteristics of control cases. Clinical and demographic characteristics of control cases.
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Additional file 2:
Clinical characteristics of Parkinson's disease cases. Clinical and demographic characteristics of Parkinson's disease cases.
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Additional file 3:
Comparison of control and Parkinson's disease cases. statistical comparison of control and Parkinson's disease cases for age, gender and post-mortem interval.
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Additional file 4:
Lack of relationship among levels of Complex I subunits and NADH-driven electron flux rates in sPD samples. Shown are data from the same sPD samples used for Figure 3.
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Additional file 5:
Sensitivity to detect low abundance heteroplasmy with Surveyor Nuclease approach. Sensitivity to detect low abundance heteroplasmy with Surveyor Nuclease approach. Shown are data from manufacturer supplied plasmids mixed in varying proportions and analyzed. (data courtesy of Caitlin Quigley).
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Additional file 6:
Cartoon showing approximate locations of amplicons for primers A-H. Cartoon showing approximate locations of amplicons for primers A-H.
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