Short report
Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease
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* Corresponding author: Dirk Motzkus dmotzkus@dpz.eu
1 Department of Infection Biology, German Primate Center, Kellnerweg 4, 37077 Goettingen, Germany
2 Center 3 Biochemistry and Molecular Cell Biology, DNA Microarray Facility, Humboldtallee 23, 37073 Goettingen, Germany
3 Prion and Dementia Research Unit, Department of Neuropathology, University of Goettingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany
4 Department of Virology and Immunology, German Primate Center, Kellnerweg 4, 37077 Goettingen, Germany
5 Department of Infection Models, German Primate Center, Kellnerweg 4, 37077 Goettingen, Germany
Molecular Neurodegeneration 2009, 4:36 doi:10.1186/1750-1326-4-36
Published: 27 August 2009Additional files
Additional file 1:
Profile of miRNA expression in cynomolgus macaque brain. Comparison of the miRNA expression profiles in the brain of cynomolgus macaques and published expression patterns of human brain.
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Additional file 2:
Relative abundance of miRNAs in human and macaque brain. Comparison of the relative abundance of miRNAs that are differentially expressed in macaque brain upon BSE-infection to the abundance in human brain. Analysis was accomplished using published miRNA-expression profiles from human brain derived by microarray, qRT-PCR, and a cloning strategy, respectively.
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Additional file 3:
CT-values from qRT-PCR analysis of miRNA regulation upon BSE-infection. CT-values derived from 4 independent qRT-PCR experiments comparing the expression of miRNAs hsa-miR-26a, hsa-miR-124a, hsa-miR-143, hsa-miR-145, hsa-miR-342-3p, and hsa-miR-494 in BSE-infected vs. non-infected cynomolgus macaques.
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Additional file 4:
Analysis of predicted targets for hsa-miR-342-3p and hsa-miR-494. Analysis of the target predictions for hsa-miR-342-3p and hsa-miR-494 as revealed by the public target prediction program TargetScan (release 5.1, April 2009) for involvement in neurodegeneration and neurodegenerative disorders.
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