Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

doi:10.1186/1750-1326-4-2

Molecular Neurodegeneration

Volume 4

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Minniti AN
Rebolledo DL
Grez PM
Fadic R
Aldunate R
Volitakis I
Cherny RA
Opazo C
Masters C
Bush AI
Inestrosa NC

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Minniti AN
Rebolledo DL
Grez PM
Fadic R
Aldunate R
Volitakis I
Cherny RA
Opazo C
Masters C
Bush AI
Inestrosa NC
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Research article

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

Alicia N Minniti¹ , Daniela L Rebolledo¹ , Paula M Grez¹ , Ricardo Fadic² , Rebeca Aldunate¹ , Irene Volitakis³ , Robert A Cherny³ , Carlos Opazo⁴ , Colin Masters³ , Ashley I Bush³^,5 and Nibaldo C Inestrosa¹

¹Centro de Regulación Celular y Patología "Joaquín V. Luco" (CRCP), MIFAB, Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, 8331010 Santiago, Chile

²Departamento de Neurología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

³Oxidation Disorders Laboratory, Mental Health Research Institute of Victoria and Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia

⁴Laboratorio de Neurobiometales, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile

⁵Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA

author email corresponding author email

Molecular Neurodegeneration 2009, 4:2doi:10.1186/1750-1326-4-2


Published:	6 January 2009

Additional files

Additional file 1:

Aβ transgenic C. elegans and controls have similar life spans. Survival curves of control worms and Aβ worms cultured on regular agar medium. Comparison of survival curves using the Log-rank (Mantel-Cox) test yielded a p = 0.1. Survival curves are not different.

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Additional file 2:

Aβ transgenic C. elegans are protected from Cu²⁺toxicity in motility assays. Representative video of thrashing assays (movement in liquid medium) performed on control worms of 168 h cultured on 150 μM copper supplemented agar.