Research article
GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects
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* Corresponding author: T Chris Gamblin gamblin@ku.edu
Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
Molecular Neurodegeneration 2009, 4:18 doi:10.1186/1750-1326-4-18
Published: 2 May 2009Additional files
Additional file 1:
Polymerization of 0N3R and 0N4R isoforms with 75 μM ARA into larger aggregates is seen, but infrequent. 0N3R (A, C, E) and 0N4R (B, D, F) isoforms exhibit filament elongation and clustering under non-phosphorylated conditions. Reactions from Figure 2 were visualized by TEM at 20,000× magnification. Each image is from a different trial, and was found to occur at about 1–3 times per grid. Scale bars represent 1 μm.
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