Figure 4.

24-OHC increases processing of APP via the non-amyloidogenic pathway. Western blot (a) and densitometric analyses (b) demonstrating increased levels of sAPPα in medium of 24-OHC-treated cells. Treatment with 27-OHC or a mixture of 24-OHC + 27-OHC did not influence sAPPα levels. Levels of Aβ40 were not affected by treatment with 24-OHC, 27-OHC, or a mixture of 24-OHC + 27-OHC compared to levels in control cells (c). *p < 0.05 (One way ANOVA followed by Dunnett's multiple comparison test).