27-OHC, but not 24-OHC, increases levels of APP and BACE1. Representative Western blots (a) and densitometric (b) analysis demonstrating increased levels of APP with 27-OHC. No changes were found in levels of APP with 24-OHC or 24-OHC+ 27-OHC treatment. BACE1 levels were unchanged with 24-OHC treatment but significantly increased with 27-OHC or a mixture of 24-OHC + 27-OHC. *p < 0.05, **p < 0.01 (One way ANOVA followed by Dunnett's multiple comparison test).
Prasanthi et al. Molecular Neurodegeneration 2009 4:1 doi:10.1186/1750-1326-4-1