Figure 1.

27-OHC, but not 24-OHC, increases levels of secreted Aβ42. While treatment with 5, 10 and 25 μM 24-OHC did not alter Aβ42 levels (a), treatment with 5, 10 and 25 μM 27-OHC significantly increased levels of Aβ42 compared to levels in medium of untreated cells (b). There was no difference in Aβ42 levels between untreated cells and cells treated with a mixture of 24-OHC + 27-OHC (c). **p < 0.01 (One way ANOVA followed by Dunnett's multiple comparison test).