Table 1 |
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Heparin Modulation of the Wnt-3a ligand Effect on the Survival of Hippocampal Neurons Exposed to the Aβ peptide |
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Treatment |
Cell Survival (%) |
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|
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|
Control |
100.0 ± 6.1 |
|
Aβ |
51.4 ± 2.9 |
|
Aβ + Wnt-3A |
75.9 ± 4.3 |
|
Aβ + Wnt-3A + heparin 0.1 μg/ml |
88.3 ± 6.0 * |
|
Aβ + Wnt-3A + heparin 1.0 μg/ml |
103.1 ± 8.5 * |
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|
|
|
Values represent means ± s.d. of three experiments carried out in triplicate. Hippocampal neurons were pretreated with Wnt-3a ligand with or without heparin for 1 h previous to the addition of 5 mM Aβ1–40. Neurons were then incubated for 24 h and MTT reduction was determined. * Indicates P < 0.05 compared with respect to Aβ + Wnt-3a in a "T" test analyzed by the Sigma plot 2.0 program. |
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Inestrosa and Toledo Molecular Neurodegeneration 2008 3:9 doi:10.1186/1750-1326-3-9 |
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