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Transient transfection of various PS1 constructs in HEK-293 cells derived stable cell lines expressing APP carrying Swedish mutation (H125-16). |
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| Cell Line |
Transfected PS1 Constructs |
Ratio of Aβ42/Aβ |
|
|
||
| H125.3-16 |
PS1 |
0.082 ± 0.022 |
| " |
PS1-D385TG |
0.261 ± 0.029** |
| " |
PS1-D385TA |
0.212 ± 0.007** |
| " |
PS1-D257TA/D385TG |
0.186 ± 0.010** |
| " |
PS1- D257TG/D385TA |
0.171 ± 0.005** |
|
Aβ40 and Aβ42 levels were measured 48 hrs post-transfection. ** p < 0.01 (versus PS1 wt) N = 3 Changed residue in the DTG motif was shown in underlined. | ||
Carter et al. Molecular Neurodegeneration 2008 3:6 doi:10.1186/1750-1326-3-6 |
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