|
Examination of Aβ values from conditioned media of HEK-293 derived stable cell lines expressing both Swedish APP and each of PS1 genes. |
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| Cell Line |
Transfected PS1 Constructs |
Aβ1–40 (pg/ml) |
Aβ1–42 (pg/ml) |
Ratio of Aβ42/Aβ |
|
|
||||
| H125.3-16 |
---- |
3152 ± 47 (n = 6) |
337 ± 36 (n = 6) |
0.097 ± 0.010 |
| " |
PS1 |
8379 ± 170 (n = 3) |
1123 ± 20 (n = 6) |
0.118 ± 0.002 |
| " |
PS1-M146V |
9507 ± 129 (n = 3) |
2627 ± 52 (n = 3) |
0.217 ± 0.004** |
| " |
PS1-D257TG |
9716 ± 192 (n = 3) |
1099 ± 35 (n = 6) |
0.102 ± 0.003* |
| " |
PS1-D385TG |
7783 ± 225 (n = 3) |
16647 ± 799 (n = 3) |
0.681 ± 0.033** |
| " |
PS1-D257TG/D385TG |
5390 ± 218 (n = 3) |
6941 ± 97 (n = 3) |
0.563 ± 0.008** |
|
n = 3 to 6 wells in one experiment. Aβ represents total Aβ. *, p < 0.001, **, p < 0.0001 as compared to PS1 wt transfected cells | ||||
Carter et al. Molecular Neurodegeneration 2008 3:6 doi:10.1186/1750-1326-3-6 |
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