Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

doi:10.1186/1750-1326-3-6

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Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

Donald B Carter, Edwige Dunn, Adele M Pauley, Denise D McKinley, Timothy J Fleck, Brenda R Ellerbrook, Nancy C Stratman, Xiangdong Zhou, Carol S Himes, Jeffrey S Nye, Alfredo Tomasselli^* and Riqiang Yan^*

* Corresponding authors: Alfredo Tomasselli alfredo.tomasselli@pfizer.com - Riqiang Yan yanr@ccf.org

Molecular Neurodegeneration 2008, 3:6 doi:10.1186/1750-1326-3-6

Molecular Neurodegeneration

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Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

Molecular Neurodegeneration

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Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1