Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

Danling Wang¹^,2 , Beisha Tang²^,3 , Guohua Zhao²^,3 , Qian Pan² , Kun Xia² , Rolf Bodmer¹ and Zhuohua Zhang¹^,2

¹Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA

²National Laboratory of Medical Genetics, Xiangya Hospital, Central South University, Changsha, Hunan, China

³Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China

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Molecular Neurodegeneration 2008, 3:3doi:10.1186/1750-1326-3-3


Published:	8 February 2008

Additional files

Additional file 1:

Amino acid sequence alignment of hLRRK2 and dLRRK. The data provided the amino acid sequence alignment of hLRRK2 and dLRRK. hLRRK2 amino acid sequences (NP_940980) and dLRRK amino acid sequences (CG5483, NP_650903) are from NCBI protein database. Alignment was done with MacVector™ 7.2.2. "*" Indicates identical amino acids between the two sequences. "." Indicates conserved amino acids between the two sequences. Highlighted purple indicates Roc GTPase domain. Highlighted red indicates kinase domain. Highlighted blue indicates the conserved PD associated point mutation sites between human and Drosophila.

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