Bdnf promoter-specific expression analyses in R6/2 cortex. Relative expression ratios to the geometric mean of three housekeeping genes for Bdnf promoter-specific transcripts in R6/2 (filled bars) and littermate wild-type controls (open bars). Data from 4, 8, 12 and 15 weeks (4 w, 8 w, 12 w and 15 w) represents the pathogenic time course from pre-symptomatic stages through to late symptomatic stages for Bdnf promoter-specific transcripts (A) I, (B) IIa, (C) IIb, (D) IIc, (E) III, (F) IV, (G) V and (H) coding exon VIII, according to Liu et al., 2006 . Error bars are S.E.M (n = 8), * p < 0.05, ** p < 0.01, *** p < 0.001.
Benn et al. Molecular Neurodegeneration 2008 3:17 doi:10.1186/1750-1326-3-17