Figure 5.

PS ablation-dependent expression changes in cathepsin and complement transcripts as a function of postnatal age. The expression changes of 5 cathepsin (Ctsc, Ctsd, Ctsh, Ctss and Ctsz) and 5 complement system transcripts (C1qa, C1qb, C1qc, C3ar1 and C4b) were examined in more detail. In both graphs X axis denotes age of mice, while Y axis denotes pairwise expression difference between the PSKO mice and matched WT samples. Each color line represents change in expression over time for a single gene. A) FC. B) HC. Note the similarity of the age-dependent transcript increase in the PSKO animals across the two brain regions.