Figure 1.

Experimental Design. The frontal cortical (FC) and hippocampal (HC) transcriptome of PS1/PS2 double-knockout animals (KO) was compared to that of wild-type controls (WT) using Affymetrix oligonucleotide microarrays. The samples from 5 different ages for each microarray were prepared from a pool of 3 animals. Data were GCOS segmented, gcRMA normalized and compared using several experimental paradigms, all employing pairwise comparison statistics.