Figure 4.

Ginkgolide B protects hippocampal neurons against Aβ_1–42-induced loss of synaptophysin. The synaptophysin content of untreated hippocampal neurons (solid circle) or hippocampal neurons pre-treated for 3 hours with 1 μM ginkgolide B (hollow circle) and subsequently incubated with different concentrations of Aβ_1–42 for 24 hours as shown. Values shown are the mean synaptophysin content ± SD from 9 observations.