Figure 1.

Aβ_1–42 causes a dose-dependent reduction in the synaptophysin content of neurons. The synaptophysin content of cortical neuronal cultures treated for 24 hours with varying concentrations of Aβ_1–42 (solid circle), Aβ_42-1 (hollow circle) or Aβ_1–40 (solid triangle). Values shown are the mean synaptophysin content ± SD from 12 observations.