Table 1

Differential expression of genes in brains of APP23 mice treated with T0 or vehicle. Fold change is expressed as ratio of vehicle versus T0 induced expression level, at p < 0.05.
Fold change
 Gene symbol
 Gene product/cluster


Up-regulated


Lipid metabolism and transport


4.60
 Fabp1
 fatty acid binding protein 1, liver
3.40
 Acaa1b
 acetyl-Coenzyme A acyltransferase 1B
2.70
 Gc
 group specific component (transport of vitamin D sterols)
2.27
 Apoa2
 apolipoprotein A-II
2.27
 Apoc1
 apolipoprotein C-I
1.75
 Abca1
 ATP-binding cassette, sub-family A (ABC1), member 1 (3 copies)
1.60
 Hmgcs2
 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
1.59
 Apod
 apolipoprotein D
1.56
 Cpt1a
 carnitine palmitoyltransferase 1a, liver
1.49
 Apoc3
 apolipoprotein C-III
1.37
 Scd1
 stearoyl-Coenzyme A desaturase 1





Metabolism of xenobiotics and detoxification


5.45
 Cyp3a11
 cytochrome P450, family 3, subfamily a, polypeptide 11
2.07
 Cyp4a10
 cytochrome P450, family 4, subfamily a, polypeptide 10
1.90
 Cyp2e1
 cytochrome P450, family 2, subfamily e, polypeptide 1
1.85
 Cyp2c29
 cytochrome P450, family 2, subfamily c, polypeptide 29
1.74
 Ugt1a2
 UDP glucuronosyltransferase 1 family, polypeptide A2 (3 copies)
1.57
 Adh1
 alcohol dehydrogenase 1 (class I)





Down-regulated


Immune response and response to stress and inflammation


3.60
 Igk-V28
 immunoglobulin kappa chain variable 28 (V28)
2.33
 Serpina3n
 serine (or cysteine) peptidase inhibitor, clade A, member 3N
1.93
 Ngp
 neutrophilic granule protein
1.90
 Gp49a
 glycoprotein 49 A /// leukocyte immunoglobulin-like receptor
1.68
 Ifitm1
 interferon induced transmembrane protein 1
1.63
 Tirap
 toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
1.62
 Gbp2
 guanylate nucleotide binding protein 2
1.58
 Fcgr2b
 Fc receptor, IgG, low affinity IIb
1.52
 Cd74
 CD74 antigen (invariant polypeptide of MCH, class II antigen-associated)
1.50
 Tnfaip6
1.49
 H2-Aa
 tumor necrosis factor alpha induced protein 6
1.49
 Aif1
 histocompatibility 2, class II antigen A, alpha
1.46
 Gbp4
 allograft inflammatory factor 1
1.40
 H2-D1
 guanylate nucleotide binding protein 4
1.40
 Hif3a ///
 histocompatibility 2, D region locus 1

LOC64109
 hypoxia inducible factor 3, alpha subunit /// similar to hypoxia inducible factor 3, alpha subunit





Cell death and apoptosis


2.15
 Wwox
 WW domain-containing oxidoreductase
1.65
 Card10
 caspase recruitment domain family, member 10
1.58
 Hccs
 holocytochrome c synthetase
1.55
 Elmo1
 engulfment and cell motility 1, ced-12 homolog (C. elegans)
1.39
 Fadd
 Fas (TNFRSF6)-associated via death domain
1.50
 Hccs
 holocytochrome c synthetase
1.39
 Sphk1
 sphingosine kinase 1

Lefterov et al. Molecular Neurodegeneration 2007 2:20   doi:10.1186/1750-1326-2-20