Figure 2.

Quantification of neuronal levels of isoprostanes. A. Computer assisted image analysis reveals pyramidal neurons from cases of AD (n = 10) reveal significantly higher levels of 8-iso-PGF_2α (p < 0.01) and13,14-dihydro 15-keto PGF_2α (p < 0.001) than aged controls (n = 10). Mann-Whitney U-test. Data shown expresses mean +/- SEM. B. In the aged control cases, neuronal levels of 8-iso-PGF_2α are significantly correlated with the numbers of AT8-positive NFT.