Figure 2.

Schematic representation of members of the LDLR family. Members of the LDLR family have diverse functions from cholesterol metabolism, Reelin and Wnt signalling, to intracellular transport. Despite multiple functions, they share common structural motifs, including ligand-binding repeats, epidermal growth factor (EGF) repeats, YWTD spacer domains, a single transmembrane domain and a short cytoplasmic domain containing conserved endocytic motifs. FN, fibronectin.