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1.
895 Accesses
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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen Molecular Neurodegeneration 2012, 7:2 (9 January 2012)
Abstract | Provisional PDF
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2.
813 Accesses
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α-Synuclein and neuronal cell death
Mark R Cookson Molecular Neurodegeneration 2009, 4:9 (4 February 2009)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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3.
813 Accesses
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Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu, Fred H Gage Molecular Neurodegeneration 2011, 6:85 (22 December 2011)
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4.
798 Accesses
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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar Molecular Neurodegeneration 2011, 6:88 (28 December 2011)
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Editor’s summary
BACE1 inhibitor drugs are currently being developed for the treatment of Alzheimer's disease, however findings suggest that BACE1 is required in axon guidance of olfactory sensory neurons, and its inhibition may cause defects.
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5.
557 Accesses
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Adeno-Associated Virus-Mediated Brain Delivery of 5-Lipoxygenase modulates the AD-like phenotype of APP mice
Jin Chu, Phillip F. Giannopoulos, Carolina Ceballos-Diaz, Todd E. Golde, Domenico Pratico Molecular Neurodegeneration 2012, 7:1 (5 January 2012)
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6.
531 Accesses
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The Alzheimer's disease β-secretase enzyme, BACE1
Sarah L Cole, Robert Vassar Molecular Neurodegeneration 2007, 2:22 (15 November 2007)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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7.
480 Accesses
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The amyloid precursor protein: beyond amyloid
Hui Zheng, Edward H Koo Molecular Neurodegeneration 2006, 1:5 (3 July 2006)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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8.
451 Accesses
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Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven Molecular Neurodegeneration 2012, 7:3 (16 January 2012)
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9.
375 Accesses
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Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
Trent M Woodruff, John Thundyil, Sung-Chun Tang, Christopher G Sobey, Stephen M Taylor, Thiruma V Arumugam Molecular Neurodegeneration 2011, 6:11 (25 January 2011)
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10.
346 Accesses
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Dopamine and α-synuclein dysfunction in Smad3 null mice
Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capelo Molecular Neurodegeneration 2011, 6:72 (13 October 2011)
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11.
327 Accesses
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Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet, Robert H Schiestl Molecular Neurodegeneration 2011, 6:83 (13 December 2011)
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12.
312 Accesses
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All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Philipp A Jaeger, Tony Wyss-Coray Molecular Neurodegeneration 2009, 4:16 (6 April 2009)
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13.
305 Accesses
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Microglial p38alpha MAPK is critical for LPS-induced neuron degeneration through a mechanism involving TNFalpha
Bin Xing, Adam D Bachstetter, Linda J Van Eldik Molecular Neurodegeneration 2011, 6:84 (20 December 2011)
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14.
298 Accesses
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Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Byung Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel Molecular Neurodegeneration 2011, 6:86 (22 December 2011)
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15.
281 Accesses
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Does neuroinflammation fan the flame in neurodegenerative diseases?
Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine, Malú G Tansey Molecular Neurodegeneration 2009, 4:47 (16 November 2009)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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16.
262 Accesses
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Heat shock protein 90 in neurodegenerative diseases
Wenjie Luo, Weilin Sun, Tony Taldone, Anna Rodina, Gabriela Chiosis Molecular Neurodegeneration 2010, 5:24 (3 June 2010)
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17.
261 Accesses
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Alzheimer's disease: synaptic dysfunction and Aβ
Ganesh M Shankar, Dominic M Walsh Molecular Neurodegeneration 2009, 4:48 (23 November 2009)
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18.
259 Accesses
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Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent, Gopal Thinakaran Molecular Neurodegeneration 2011, 6:87 (28 December 2011)
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19.
251 Accesses
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GSK3 and p53 - is there a link in Alzheimer's disease?
Carole J Proctor, Douglas A Gray Molecular Neurodegeneration 2010, 5:7 (26 January 2010)
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20.
232 Accesses
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Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology
Steve Pedrini, Carlos Thomas, Hannah Brautigam, James Schmeidler, Lap Ho, Paul Fraser, David Westaway, Peter Hyslop, Ralph N Martins, Joseph D Buxbaum, Giulio M Pasinetti, Dara L Dickstein, Patrick R Hof, Michelle E Ehrlich, Sam Gandy Molecular Neurodegeneration 2009, 4:40 (21 October 2009)
Abstract | Full text | PDF | PubMed
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Editor’s summary
The importance of diet in the pathogenesis of Alzheimer’s disease is becoming clear and new data suggests a correlation between dietary derived factors and sensitization of brain neurons favoring neurotoxicity.
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21.
223 Accesses
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Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp, Kurt F Hauser Molecular Neurodegeneration 2011, 6:78 (17 November 2011)
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22.
219 Accesses
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The role of tau in neurodegeneration
Tania F Gendron, Leonard Petrucelli Molecular Neurodegeneration 2009, 4:13 (11 March 2009)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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23.
214 Accesses
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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis, Leonard Petrucelli Molecular Neurodegeneration 2011, 6:73 (26 October 2011)
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24.
213 Accesses
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Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel Molecular Neurodegeneration 2011, 6:36 (27 May 2011)
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25.
209 Accesses
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Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity
Pedro J Chacon, Rosa Garcia-Mejias, Alfredo Rodriguez-Tebar Molecular Neurodegeneration 2011, 6:14 (4 February 2011)
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